Five hundred and twenty-nine patients attended five different clinics supervised in three different ways in two adjacent, but socially different, health districts. Performance was apparently better in the clinics supervised by the consultant personally or by specialised junior staff. Non-atopic asthma appeared to be more frequent in clinics attended by patients with a social advantage, where it also appeared to be more easily controlled. This difference in control was less apparent in atopic asthma. These differences and deliberate selection probably account for the differences in performance between the clinics. Prescription policy appeared to be uniform throughout the clinics, though there was a tendency for drugs to be given at a lower level of pulmonary function in those clinics where performance was generally worse. Five per cent of all patients failed to achieve satisfactory treatment after a whole year's observation. This was not influenced by supervision or social group. Analysis of the pulmonary function of patients for whom drugs had been prescribed suggested that there was possible under-use of disodium cromoglycate as opposed to inhaled corticosteroids. The exercise proved a rapid and useful assessment of the performance of the clinics supervising asthma.
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Arch Bronconeumol
December 2024
Pulmonology Service, Cruces University Hospital (OSI EEC), Barakaldo, Spain; BioBizkaia Health Research Institute, Spain.
The Spanish Society of Pneumology and Thoracic Surgery (SEPAR) and the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) have developed together Clinical Practice Guidelines (GPC) on the management of people affected by tuberculosis (TB) resistant to drugs with activity against Mycobacterium tuberculosis. These clinical practice guidelines include the latest updates of the SEPAR regulations for the diagnosis and treatment of drug-resistant TB from 2017 and 2020 as the starting point. The methodology included asking relevant clinical questions based on PICO methodology, a literature search focusing on each question, and a systematic and comprehensive evaluation of the evidence, with a summary of this evidence for each question.
View Article and Find Full Text PDFInt J Gen Med
December 2024
Department of Thyroid and Breast Surgery, Quzhou People's Hospital, Quzhou, 324000, People's Republic of China.
Objective: This study aims to demonstrate the impact of sarcopenia on the prognosis of early breast cancer and its role in early multimodal intervention.
Methods: The clinical data of patients (n=285) subjected to chemotherapy for early-stage breast cancer diagnosed pathologically between January 1, 2016, and December 31, 2020, in our hospital were retrospectively analyzed. Accordingly, the recruited subjects were divided into sarcopenia (n=85) and non-sarcopenia (n=200) groups according to CT diagnosis correlating with single-factor and multifactorial logistic regression analyses.
Recent advancements in large language models (LLMs) like ChatGPT and LLaMA have shown significant potential in medical applications, but their effectiveness is limited by a lack of specialized medical knowledge due to general-domain training. In this study, we developed Me-LLaMA, a new family of open-source medical LLMs that uniquely integrate extensive domain-specific knowledge with robust instruction-following capabilities. Me-LLaMA comprises foundation models (Me-LLaMA 13B and 70B) and their chat-enhanced versions, developed through comprehensive continual pretraining and instruction tuning of LLaMA2 models using both biomedical literature and clinical notes.
View Article and Find Full Text PDFActa Otorhinolaryngol Ital
December 2024
Unit of Audiology, Regional Centre of Cochlear Implants and ENT Diseases, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy.
Objectives: This research aims to validate the digits-in-noise (DIN) test for the Italian language and develop a version capable of independently assessing both ears while maintaining acceptable administration times.
Methods: Individual digits from 0 to 9 in Italian were recorded and adjusted to equalise recognition probabilities. An iOS application (APP) was developed for the independent ear test using triplets in noise.
J Korean Med Sci
January 2025
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Background: The accuracy of Logical Observation Identifiers Names and Codes (LOINC) mappings is reportedly low, and the LOINC codes used for research purposes in Korea have not been validated for accuracy or usability. Our study aimed to evaluate the discrepancies and similarities in interoperability using existing LOINC mappings in actual patient care settings.
Methods: We collected data on local test codes and their corresponding LOINC mappings from seven university hospitals.
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