AI Article Synopsis
- Intracarotid injection of cytidoline (at doses of 2, 4, or 8 mg/kg) reduces the depression of evoked cortical potentials during short episodes of cerebral ischemia.
- Research on hypercapnic cats indicates that this protective effect is primarily due to metabolic factors instead of changes in blood flow.
- There's evidence suggesting that cytidoline may engage central dopaminergic structures, based on earlier findings.
Article Abstract
The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participation of the central dopaminergic structures by the drug is suggested according to the previous data.
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| http://dx.doi.org/10.1159/000136830 | DOI Listing |
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