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Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes.
Prog Lipid Res
April 2014
Centre for Pharmacology and Toxicology, Hannover Medical School, 30625 Hannover, Germany. Electronic address:
Triacyglycerols are a major energy reserve of the body and are normally stored in adipose tissue as lipid droplets (LDs). The liver, however, stores energy as glycogen and digested triglycerides in the form of fatty acids. In stressed condition such as obesity, imbalanced nutrition and drug induced liver injury hepatocytes accumulate excess lipids in the form of LDs whose prolonged storage leads to disease conditions most notably non-alcoholic fatty liver disease (NAFLD).
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