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Discovering and targeting mitochondrial loss in NOTCH1-related aortic aneurysm.
Nat Cardiovasc Res
January 2025
Mitochondrial NAD deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm.
Nat Cardiovasc Res
January 2025
Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Thoracic and abdominal aortic aneurysm poses a substantial mortality risk in adults, yet many of its underlying factors remain unidentified. Here, we identify mitochondrial nicotinamide adenine dinucleotide (NAD)⁺ deficiency as a causal factor for the development of aortic aneurysm. Multiomics analysis of 150 surgical aortic specimens indicated impaired NAD salvage and mitochondrial transport in human thoracic aortic aneurysm, with expression of the NAD transporter SLC25A51 inversely correlating with disease severity and postoperative progression.
View Article and Find Full Text PDFPersistent pain and fever unmasking aortic angiosarcoma at the site of previous endovascular aortic repair.
BMJ Case Rep
January 2025
The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Aortic angiosarcomas are extremely rare and difficult to diagnose. Here, we report a case of persistent pain and fever of unknown origin, culminating in the diagnosis of aortic epithelioid angiosarcoma at the site of a previous Dacron aortic graft.
View Article and Find Full Text PDFProtective effect of ulinastatin against negative inflammatory response and organ dysfunction in acute aortic dissection surgery: The PANDA trial.
Cell Rep Med
January 2025
Department of Cardiovascular Surgery, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Ulinastatin is a protease-inhibiting drug with anti-inflammatory and other pharmacological properties. Little is known regarding its role following acute type A aortic dissection (ATAAD) surgery. We perform a randomized controlled trial to investigate the protective effect of ulinastatin against negative inflammatory response and organ dysfunction in ATAAD surgery (PANDA).
View Article and Find Full Text PDFComparison of Woven EndoBridge and stent-assisted coiling for treatment of acutely ruptured wide-neck bifurcation aneurysms: Single-center experience.
J Cerebrovasc Endovasc Neurosurg
January 2025
Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran.
Objective: Treating wide-necked bifurcation aneurysms (WNBA) is challenging. Nevertheless, recent progress in endovascular techniques is promising. Woven EndoBridge devices (WEB) have exhibited outcomes comparable to conventional treatments like stent-assisted coiling (SAC) in treating aneurysms.
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