The study of hemolysin activity, hemolysin-destructive factor (HDF) activity and cholerogenicity in 143 Vibrio eltor strains has revealed the existance of close relationship between cholerogenicity and hemolysin production, as well as between cholerogenicity and HDF activity. The negative character of conjugation between the HDF activity and the hemolytic activity of the strains under study has been established, which allows one to suggest the possibility of the regulating action of hemolysin on the synthesis of HDF (enterotoxin).
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