If 60 min long ischemia of a liver tissue lobe occurred after feeding of rats with oil emulsion of alpha-tocopherol at a dose of 50 mg/kg within 12 hrs during 2 days, the "ischemic" decrease in metabolism of amidopyrine and aniline, in content of cytochrome P-450 and activity of initial and middle steps of NADPH-dependent redox chain as well as intensification of ascorbate-dependent peroxidation of membrane lipids were prevented in endoplasmic reticulum of hepatocytes. The protective effect of alpha-tocopherol on these xenobiotics metabolism is apparently related to an increase in catalytic activity of cytochrome P-450, to the enzyme antioxidant and membrane-stabilizing properties.
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