A physiologically based model of the neocortex has been developed in an attempt to elucidate possible structural and functional mechanisms of the mammalian cortex and account for a wide range of low level cognitive behavior. The model has been constrained by diverse empirical data. At the level of structural details, neuroanatomical and neurophysiological data have been considered and at the level of gross behavior, psychological data has been used. From the theory that groups of reverberating neurons provide a short term memory mechanism and that primary drive reduction triggers consolidation of a memory, a mechanism for selective learning has been developed. Fundamental to the model is the postulate of a novelty drive mechanism that functions in a manner analogous to the more widely accepted primary drives (e.g. hunger and fear). This paper examines the novelty drive mechanism and demonstrates its utility in accounting for a wide range of habituation behaviors. The success of the model is evaluated by comparing its behavior to appropriate empirical data. Finally, it is argued that a computer program is both a theory and a model, and that important advantages accrue from such a viewpoint.
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http://dx.doi.org/10.1016/0022-5193(83)90442-3 | DOI Listing |
Genome
January 2025
Damietta University Faculty of Science, New Damietta, Damietta, Egypt;
Polyamine oxidase (PAOs) are enzymes associated with polyamine catabolism and play important roles in growth and development and stress tolerance of plants. In the present study, genome-wide discovery and analysis of the PAO family in sorghum was done utilizing model PAO of Arabidopsis. Six PAO genes were found using publicly available genomic data.
View Article and Find Full Text PDFAnnu Rev Biomed Data Sci
January 2025
1Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California, USA;
Cancer remains a leading cause of death globally. The complexity and diversity of cancer-related datasets across different specialties pose challenges in refining precision medicine for oncology. Foundation models offer a promising solution.
View Article and Find Full Text PDFJ Speech Lang Hear Res
January 2025
Program for Early Autism Research, Leadership, and Service, The University of North Carolina at Chapel Hill.
Purpose: Intentional communication acts, or purposefully directed vocalizations and gestures, are particularly difficult for infants at elevated likelihood for eventual diagnosis of autism. The ability to measure and track intentional communication in infancy thus has the potential to aid early identification and intervention efforts. This study assesses the validity of a novel measure of intentional communication intended for use within semistructured caregiver-infant interactions.
View Article and Find Full Text PDFSci Adv
January 2025
Center for Quantum Information, Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, PR China.
Quantum simulators with hundreds of qubits and engineerable Hamiltonians have the potential to explore quantum many-body models that are intractable for classical computers. However, learning the simulated Hamiltonian, a prerequisite for any quantitative applications of a quantum simulator, remains an outstanding challenge due to the fast increasing time cost with the qubit number and the lack of high-fidelity universal gate operations in the noisy intermediate-scale quantum era. Here, we demonstrate the Hamiltonian learning of a two-dimensional ion trap quantum simulator with 300 qubits.
View Article and Find Full Text PDFSci Adv
January 2025
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710069, China.
Heteroarene skeletal editing is gaining popularity in synthetic chemistry. Transmuting single atoms generates molecules that have distinctly varied properties, thereby fostering potent molecular exchanges that can be extensively used to synthesize functional molecules. Herein, we present a convenient protocol for nitrogen-carbon single-atom transmutations in isoquinolines, which is inspired by the Wittig reaction and enables easy access to substituted naphthalene derivatives.
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