Distribution of the intervals between spikes of 50 neurons in the posterior hypothalamus were studied in 17 unanesthetized rabbits. Three main types of the interspike-interval distribution were found in the thermoneutral zone: 1) unimodal, mode 2-4 ms; 2) unimodal, mode 16-512 ms; 3) bimodal, modes 2-10 ms and 64-512 ms (the posterior hypothalamus temperature was 39.1 +/- 0.02 degrees C). When the posterior hypothalamus temperature was increased or decreased (by 0.5-1.5 degrees C), changes in the initial interspike-interval distributions were observed in 11 neurons. The changes disappeared when the thermal stimuli were removed; 6 neurons (of 11) altered the mean firing rates too when the posterior hypothalamus temperature was changed.
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Int J Mol Sci
January 2025
Laboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, H1094 Budapest, Hungary.
The ability to reproduce depends on metabolic status. In rodents, the ventral premammillary nucleus (PMv) integrates metabolic and reproductive signals. While leptin (adiposity-related) signaling in the PMv is critical for female fertility, male reproductive functions are strongly influenced by glucose homeostasis.
View Article and Find Full Text PDFBrain Sci
January 2025
Department of Physiology, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea.
The significant correlation between ancient medicinal practices and brain function marks a revolutionary frontier in the field of neuroscience. Acupuncture, a traditional oriental medicine, can affect brain regions, such as the hypothalamus, anterior cingulate, posterior cingulate, and hippocampus, and produces specific therapeutic effects, such as pain relief, suppression of hypertension, and alleviation of drug addiction. Among the brain regions, the hypothalamus, a small yet critical region in the brain, plays a pivotal role in maintaining homeostasis by regulating a wide array of physiological processes, including stress responses, energy balance, and pain modulation.
View Article and Find Full Text PDFInflamm Res
January 2025
Medical Faculty and University Hospital, Institute of Neural and Sensory Physiology, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Background: Adenosine, an ATP degradation product, is a sleep pressure factor. The adenosine 1 receptor (A1R) reports sleep need. Histaminergic neurons (HN) of the tuberomamillary nucleus (TMN) fire exclusively during wakefulness and promote arousal.
View Article and Find Full Text PDFJ Neurophysiol
January 2025
Department of Foundational Sciences and Humanities, Discipline of Cellular & Molecular Pharmacology, Rosalind Franklin University, North Chicago, IL, USA, 60064.
The medial amygdala (MeA) is activated by social stimuli and manipulations of the MeA disrupt a wide range of social behaviors. Social stress can shift social behaviors and may accomplish this partly via effects on the MeA. However, very little is known about the effects of social stress on the electrophysiological activity of MeA neurons.
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