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Novel Selectable Marker Sesquiterpenoid Antibiotic Pentalenolactone.
Int J Mol Sci
December 2024
Center for Molecular and Cellular Biology, 121205 Moscow, Russia.
Antibiotic resistance has been and remains a major problem in our society. The main solution to this problem is to search and study the mechanisms of antibiotic action. Many groups of secondary metabolites, including antimicrobial ones, are produced by the phylum.
View Article and Find Full Text PDFIsolation and Identification of Pentalenolactone Analogs from sp. NRRL S-4.
Molecules
December 2021
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China.
Terpene synthases are widely distributed in Actinobacteria. Genome sequencing of sp. NRRL S-4 uncovered a biosynthetic gene cluster (BGC) that putatively synthesizes pentalenolactone type terpenes.
View Article and Find Full Text PDFPentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis.
J Antibiot (Tokyo)
January 2011
Laboratory of Microbial Engineering, Kitasato Institute for Life Sciences, Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan.
Pentalenic acid (1) has been isolated from many Streptomyces sp. as a co-metabolite of the sesquiterpenoid antibiotic pentalenolactone and related natural products. We have previously reported the identification of a 13.
View Article and Find Full Text PDFA gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis.
Biochemistry
May 2006
Department of Chemistry, Brown University, Box H, Providence, Rhode Island 02912-9108, USA.
Streptomyces avermitilis, an industrial organism responsible for the production of the anthelminthic avermectins, harbors a 13.4 kb gene cluster containing 13 unidirectionally transcribed open reading frames corresponding to the apparent biosynthetic operon for the sesquiterpene antibiotic pentalenolactone. The advanced intermediate pentalenolactone F, along with the shunt metabolite pentalenic acid, could be isolated from cultures of S.
View Article and Find Full Text PDFCytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).
Biochem Biophys Res Commun
August 2003
Institute of Biological Sciences, University of Wales Aberystwyth, Aberystwyth, UK.
The genus Streptomyces produces about two-thirds of naturally occurring antibiotics and a wide array of other secondary metabolites, including antihelminthic agents, antitumor agents, antifungal agents, and herbicides. The newly completed genome sequence of the avermectin-producing bacterium Streptomyces avermitilis contains 33 cytochromes p450 (CYPs), many more than the 18 observed in Streptomyces coelicolor A3(2). Some of the likely metabolic functions are reported together with their genomic location and bioinformatic analysis.
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