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More than 1 million permanent pacemakers are implanted worldwide each year, half of which are in patients with high-grade atrioventricular block. Pacemakers provide adequate frequency support in the initial stage, but traditional right ventricular (RV) pacing may lead to or aggravate left ventricular dysfunction and arrhythmia. Several potential risk factors for heart failure and arrhythmias after pacemaker surgery have been identified, but their occurrence remains difficult to predict clinically.

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Extraction, structural characteristics, bioactivities and application of polysaccharides from Acanthopanax senticosus (Rupr. Maxim.) harms: A review.

Int J Biol Macromol

January 2025

State Key Laboratory of Integration and Innovation of Classical formula and Modern Chinese Medicines, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau. Electronic address:

Acanthopanax senticosus, a celebrated herbal remedy, has been cherished in China for its health-promoting properties for over two millennia. The plant's key bioactive constituent, A. senticosus polysaccharide (ASPS), has recently attracted significant interest due to its exceptional biological activities.

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Cross-species characterization of transcranial ultrasound propagation.

Brain Stimul

January 2025

Pazhou Lab (Guangzhou), Guangzhou, 510335, China; The School of Automation Science and Engineering, South China University of Technology, Guangzhou, 510641, China. Electronic address:

Background: Transcranial ultrasound stimulation (TUS) has shown promising prospects as a non-invasive neuromodulation technique for both animals and humans. However, ultrasonic propagation characteristics within the brain differ significantly from those in free space. There is currently a lack of comprehensive studies on the effects of skull thickness on focal point position, full width at half maximum (FWHM), and acoustic intensity.

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Advances in transcranial focused ultrasound neuromodulation for mental disorders.

Prog Neuropsychopharmacol Biol Psychiatry

January 2025

Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. Electronic address:

Mental disorders are a major public health concern, affecting millions worldwide. Current treatments have limitations, highlighting the need for novel, effective, and safe interventions. Transcranial focused ultrasound (tFUS), a non-invasive neuromodulation technology, has emerged as a promising tool for treating mental disorders due to its high controllability, precision, and safety.

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Photosynthetic Toxicological Effects of Organic Extracts from Zanthoxylum bungeanum Leaves on Controlling the Microcystis aeruginosa Blooms.

Curr Microbiol

December 2024

State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, 252000, China.

Article Synopsis
  • Recent algal blooms threaten aquatic ecosystems, making eco-friendly algae-inhibiting methods, such as using allelopathic substances, valuable for water restoration.
  • This study focused on extracting flavonoids from Zanthoxylum bungeanum leaves and examining their effects on Microcystis aeruginosa algae.
  • Optimal extraction conditions were found, and results indicated that these leaf extracts not only have good antioxidant activity but also disrupt photosystem II activity in algae, providing promising insights for controlling algal blooms and developing new algae-inhibiting agents.
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