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Prescriptions (Rx) for Prevention: Clinical Tools for Integrating Environmental Health into Pediatric Clinical Care.

J Public Health Manag Pract

January 2025

Department of Environmental Medicine and Public Health (Mr Bland, Dr Zajac, Ms Guel, Dr Pendley, Dr Galvez, Dr Sheffield), Icahn School of Medicine at Mount Sinai, New York, New York; Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (Mr Wilson), Boston, Massachusetts; Environmental Research and Translation for Health (EaRTH) Center (Ms Charlesworth), University of California, San Francisco, California; Community Engagement Core, Environmental Health Sciences Center at Department of Environmental Medicine (Dr Korfmacher), University of Rochester Medical Center, Rochester, New York; Pediatric Environmental Health and Cincinnati Children's Hospital Medical Center (Dr Newman), Cincinnati, Ohio; Philadelphia Regional Center for Children's Environmental Health, Center of Excellence in Environmental Toxicology, Perelman School of Medicine (Dr Howarth), University of Pennsylvania, Philadelphia, Pennsylvania; and Division of Academic General Pediatrics, Children's Hospital at Montefiore (Dr Balk), Albert Einstein College of Medicine, Bronx, New York.

The integration of environmental health (EH) into routine clinical care for children is in its early stages. The vision of pediatric EH is that all clinicians caring for children are aware of and able to help connect families to needed resources to reduce harmful environmental exposures and increase health-enhancing ones. Environmental exposures include air pollution, substandard housing, lead, mercury, pesticides, consumer products chemicals, drinking water contaminants, industrial facility emissions and, increasingly, climate change-related extreme weather and heat events.

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Background: Chronic stress, characterized by sustained activation of physiological stress response systems, is a key risk factor for numerous health conditions. Allostatic load (AL), a biomarker of cumulative physiological stress, offers a quantitative measure of this burden. Lifestyle habits such as alcohol consumption and smoking, alongside environmental exposures to toxic metals like lead, cadmium, and mercury, were individually implicated in increasing AL.

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Genotoxic effects in island populations of Cartagena de Indias, Colombia due to environmental exposure to mercury and cadmium.

F1000Res

January 2025

Doctorado en Medicina Tropical, Faculty of Medicine, Universidad de Cartagena, Cartagena, Bolívar, Colombia.

Background: Contamination of Cartagena Bay, Colombia with heavy metals such as mercury (Hg) and cadmium (Cd) presents a major environmental and public health concern, particularly for human communities residing on nearby islands and coastal areas. These populations face enhanced exposure risks owing to their traditional fishing practices and continuous interactions with polluted marine environments. This study aimed to evaluate the genotoxic effects of environmental exposure to Hg and Cd in populations from the island zone of the Cartagena district, Bolívar.

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Background: Metabolic-associated steatohepatitis and liver fibrosis (MASLD) is a growing public health concern, with environmental factors potentially playing a role in its development. This study aimed to investigate the associations between serum cadmium and mercury levels and the risk of MASLD in a nationally representative sample from the United States.

Methods: Data from the National Health and Nutrition Examination Survey from 1999 to 2018 were analyzed.

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Importance: Disease characteristics of genetically mediated coronary artery disease (CAD) on coronary angiography and the association of genomic risk with outcomes after coronary angiography are not well understood.

Objective: To assess the angiographic characteristics and risk of post-coronary angiography outcomes of patients with genomic drivers of CAD: familial hypercholesterolemia (FH), high polygenic risk score (PRS), and clonal hematopoiesis of indeterminate potential (CHIP).

Design, Setting, And Participants: A retrospective cohort study of 3518 Mass General Brigham Biobank participants with genomic information who underwent coronary angiography was conducted between July 18, 2000, and August 1, 2023.

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