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DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models.
Neuropharmacology
May 2024
Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China. Electronic address:
Tremendous progress has been made to develop the therapy of Alzheimer's disease (AD). Existing several anti-AD remedies, with certain limitations, are far from adequate. Evidence suggests that dihydroergocristine (DHEC) mesylate, one of the main components of Ergoloid mesylates, can reduce the production of amyloid-β in vitro.
View Article and Find Full Text PDFDihydroergotoxine mesylate for the treatment of sialorrhea in Parkinson's disease.
Parkinsonism Relat Disord
January 2019
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China. Electronic address:
Background: Many patients with Parkinson's disease (PD) suffer from sialorrhea. Sialorrhea is often treated with anticholinergics and botulinum toxin, but some adverse effects have limited the use of these treatments. Dihydroergotoxine mesylate is an α-adrenergic blocking agents as well as some affinities to the dopaminergic and serotonin (5-HT) receptors.
View Article and Find Full Text PDFValidated liquid chromatography-tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma.
J Pharm Biomed Anal
June 2016
Pharmaceutical & Fermentation Industries Development Center, City of Scientific Research and Technology Applications, New Borg El-Arab 21934, Alexandria, Egypt. Electronic address:
A simple, sensitive and rapid high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the simultaneous quantitation of clopamide, reserpine and dihydroergotoxine (ergoloid mesylates) in human plasma. Under basic conditions, liquid-liquid extraction using ethyl acetate was efficiently used for extraction of the analytes from plasma samples in presence of indapamide as internal standard (IS). The analytes were separated with isocratic elution on Phenomenex(®) Synergi Fusion-RP 80A column (50×4.
View Article and Find Full Text PDF[Effects of Tongluo Xingnao effervescent tablets on blood rheology, iNOS, VEGF and LDH-5 in MID rats].
Zhongguo Zhong Yao Za Zhi
March 2016
China Academy of Traditional Chinese Medicine, Beijing 100700, China.
The study was to explore effects of Tongluo Xingnao effervescent tablets on the blood rheology, iNOS, VEGF and LDH-5 in multi-infarct dementia(MID) model rats. Establish MID model rats were induced by microthrombosis, from which 50 successful model rats were randomly divided into five groups, such as the model control group, the dihydroergotoxine mesylate tablets(hydergine) group(0.7 mg•kg⁻¹), Tongluo Xingnao effervescent tablets high-dose, medium-dose and low-dose groups(7.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate how Tongluo Xingnao effervescent tablets affect learning and memory and the expression of Na(+)-K(+)-ATPase in the brains of rats with chronic cerebral ischemia.
- Using a 2-VO method, researchers created a model of memory dysfunction in rats, divided them into various treatment groups, and administered drugs for 90 days before testing their memory and analyzing brain tissues.
- Results showed that Tongluo Xingnao tablets improved escape latency and memory performance in tests compared to the model group, and the middle-dose group had better histopathological results and higher Na(+)-K(+)-ATPase expression.
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