Remarkable progress has been made in curing a significant number of disseminated cancers, but at times the pace has seemed discouragingly slow. When I look back at both the successes and failures, and relate them to current concepts, I cannot help but wonder if the rate of future progress might be accelerated by application of basic tenets of the 40-year-old somatic mutation theory. By this I mean serious consideration of the implications of this theory in interpretation of available data and in the design of future therapeutic regimens.
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