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YAP promotes fibrosis by regulating macrophage to myofibroblast transdifferentiation and M2 polarization in chronic pancreatitis.
Int Immunopharmacol
January 2025
Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan CN 610041, China. Electronic address:
Chronic pancreatitis (CP) is a clinical entity characterized by progressive inflammation and irreversible fibrosis of the pancreas, which ultimately leads to exocrine and/or endocrine insufficiency as well as an increased risk of pancreatic cancer. Currently, there are no specific or effective approved therapies for CP. Herein, we show that macrophage to myofibroblast transdifferentiation (MMT) and M2 macrophage polarization are associated with both human CP and CP experimental mouse models.
View Article and Find Full Text PDFDevelopment of multifunctional fluorescence-emitting potential theranostic agents for Alzheimer's disease.
Talanta
January 2025
Pharmaceutical Chemistry Research Laboratory I, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India. Electronic address:
The cholinergic deficits and amyloid beta (Aβ) aggregation are the mainstream simultaneously observed pathologies during the progression of Alzheimer's disease (AD). Deposited Aβ plaques are considered to be the primary pathological hallmarks of AD and are contemplated as promising diagnostic biomarker. Herein, a series of novel theranostic agents were designed, synthesised and evaluated against cholinesterase (ChEs) enzymes and detection of Aβ species, which are major targets for development of therapeutics for AD.
View Article and Find Full Text PDFDanshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps.
Phytomedicine
January 2025
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China,; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China, ; The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Background: The significant distal necrosis of the random-pattern skin flaps greatly restricts their clinical applications in flap transplantation. Previous studies have demonstrated the potential of danshensu (DSS) to alleviate ischemic tissue injury. However, no research to date has confirmed whether DSS can improve the survival of ischemic flaps.
View Article and Find Full Text PDFERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells.
Cell Rep
January 2025
Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, 72076 Tübingen, Baden-Württemberg, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, 72076 Tübingen, Baden-Württemberg, Germany. Electronic address:
Epithelial cells respond to infection with the intracellular bacterial pathogen Listeria monocytogenes by altering their mechanics to promote collective infected cell extrusion (CICE) and limit infection spread across cell monolayers. However, the underlying biochemical pathways remain elusive. Here, using in vitro (epithelial monolayers) and in vivo (zebrafish larvae) models of infection with L.
View Article and Find Full Text PDFActivated Graphite with Richly Oxygenated Surface from Spent Lithium-Ion Batteries for Microwave Absorption.
Small
January 2025
School of Materials and Physics & Center of Mineral Resource Waste Recycling, China University of Mining and Technology, Xuzhou, Jiangsu, 221116, China.
Designing spent graphite anodes from lithium-ion batteries (LIBs) for applications beyond regenerated batteries offers significant potential for promoting the recycling of spent LIBs. The battery-grade graphite, characterized by a highly graphitized structure, demonstrates excellent conductive loss capabilities, making it suitable for microwave absorption. During the Li-ion intercalation and deintercalation processes in battery operation, the surface layer of spent graphite (SG) becomes activated, forming oxygen-rich functional groups that enhance the polarization loss mechanism.
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