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Assessment of Genotoxicity of Zinc Oxide Nanoparticles Using Mosquito as Test Model.
Toxics
October 2023
Department of Zoology, Akal College of Basic Sciences, Eternal University, Baru Sahib, Himachal Pradesh 173101, India.
The widespread applications of ZnO NPs in the different areas of science, technology, medicine, agriculture, and commercial products have led to increased chances of their release into the environment. This created a growing public concern about the toxicological and environmental effects of the nanoparticles. The impact of these NPs on the genetic materials of living organisms is documented in some cultured cells and plants, but there are only a few studies regarding this aspect in animals.
View Article and Find Full Text PDFEvaluating the Mating Competency of Genetically Modified Male Mosquitoes in Laboratory Conditions.
Front Trop Dis
February 2023
Department of Entomology, Texas A&M University, College Station, TX 77843, USA.
Efforts to eradicate mosquito-borne diseases have increased the demand for genetic control strategies, many of which involve the release of genetically modified (GM) mosquito males into natural populations. The first hurdle for GM males is to compete with their wild-type counterparts for access to females. Here, we introduce an eye color-based mating assay, in which both wild-type and ()-null males compete for access to -null females, and therefore the eye color phenotype (black or white) of the progeny is dependent on the parental mating pair.
View Article and Find Full Text PDFMutation Effect of Ionizing and Non-Ionizing Electromagnetic Radiation on Drosophila melanogaster.
Bull Exp Biol Med
March 2023
Chelyabinsk State University, Chelyabinsk, Russia.
The frequency of D. melanogaster embryonic death was estimated using the method of dominant lethal mutations after exposure to ionizing γ-radiation and non-ionizing pulsed magnetic field. γ-Radiation had a dose-dependent mutational effect on D.
View Article and Find Full Text PDFGenotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in .
Toxicol Rep
February 2023
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken 66123, Germany.
Genotoxicity and mutagenicity of monoterpene carvone along with the related monoterpene alcohols - carvacrol and thymol have been studied using as model system. The viability, pre-imaginal stage duration, level of dominant lethal mutations, unequal crossover in the mutant of and the influence of monocyclic terpenoids on the multiplication of the nuclear genome in salivary gland cells were investigated. The compounds tested after oral administration (0.
View Article and Find Full Text PDFNovel molecular approaches to combat vectors and vector-borne viruses: Special focus on RNA interference (RNAi) mechanisms.
Acta Trop
September 2022
State Virology Laboratory, Department of Microbiology, Gandhi Medical College, Bhopal 462001, Madhya Pradesh, India.
Vector-borne diseases, such as dengue, chikungunya, zika, yellow fever etc pose significant burden among the infectious diseases globally, especially in tropical and sub-tropical regions. Globalization, deforestation, urbanization, climate change, uncontrolled population growth, inadequate waste management and poor vector-management infrastructure have all contributed to the expansion of vector habitats and subsequent increase in vector-borne diseases throughout the world. Conventional vector control methods, such as use of insecticides, have significant negative environmental repercussions in addition to developing resistance in vectors.
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