Changes in mitochondrial DNA (mtDNA) replication activity are known to occur during oogenesis in Xenopus laevis. Electron microscopic and electrophoretic analyses carried out on mtDNA molecules at different vitellogenic stages show that 1. The frequency of displacement loop (D-loop) forms is correlated with the intensity of mitochondrial biogenesis. 2. Most of the native molecules as well as the D-loop carrying ones are superhelical. 3. Four families of different superhelicity may be distinguished and D-loops are found only in the most superhelical ones. To account for the changes in the frequencies of the D-loop forms and of the different topological types during cell differentiation, it is suggested that the initiation of a new replication occurs only on the most superhelical molecules and that some control of superhelicity may exist in mitochondria.
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http://dx.doi.org/10.1016/0014-4827(83)90114-3 | DOI Listing |
Mitochondrial DNA B Resour
January 2025
Department of Wildlife, Fisheries and Aquaculture, Mississippi State University, Mississippi State, Mississippi, USA.
We present a novel mitogenome assembly of the Redlip Shiner, , and assemblies for the Greenhead Shiner, (Cypriniformes: Leuciscidae). Both are charismatic minnows in the taxonomic group and are endemic to the eastern United States. The genome contains 16,711bp and 16,706bp each comprising a total of 13 protein coding genes, 22 tRNAs, two rRNAs, and a control region.
View Article and Find Full Text PDFMitochondrial DNA B Resour
January 2025
Department of Ecology and Institute of Hydrobiology, Jinan University, Guangzhou, China.
is a popular ornamental aquatic plant for aquarists, although only six species are found in China. Destruction of the natural habitats of for human activities has led to a decline in its numbers. In this report, we sequenced and annotated the chloroplast genome for the first time.
View Article and Find Full Text PDFHeliyon
January 2025
Unit of Medical Genetics, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Sudden cardiac death (SCD) is a major health concern, which can be the sign of a latent mitochondrial disease. However, mitochondrial DNA (mtDNA) contribution is largely unexplored in SCD at population level. Recently, mtDNA variants have been associated with congenital cardiopathy and higher risk of ischemic heart disease, suggesting them as potential risk factors also in SCD.
View Article and Find Full Text PDFFront Plant Sci
January 2025
Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chongqing Institute of Medicinal Plant Cultivation, Nanchuan, Chongqing, China.
Introduction: Mitochondria are essential organelles that provide energy for plants. They are semi-autonomous, maternally inherited, and closely linked to cytoplasmic male sterility (CMS) in plants. , a widely used medicinal plant from the Caprifoliaceae family, is rich in chlorogenic acid (CGA) and its analogues, which are known for their antiviral and anticancer properties.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
January 2025
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru 570015. JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
There is a myriad of activities that involve mitochondria that are crucial for maintaining cellular equilibrium and genetic stability. In the pathophysiology of neurodegenerative illnesses, mitochondrial transcription influences mitochondrial equilibrium, which in turn affects their biogenesis and integrity. Among the crucial proteins for keeping the genome in optimal repair is mitochondrial transcription factor A, more commonly termed TFAM.
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