Survival chances of 2007 patients with pacemaker implantation were determined. For the group as a whole, five-year survival rate was 57%, ten-year survival rate 35%. The prognosis was significantly better in patients with sick-sinus syndrome than those with AV block or brady-arrhythmias. Those with sick-sinus syndrome had an expectancy which was comparable to that of the (age and sex matched) normal population, while those with brady-arrhythmia had a significantly worse ten-year survival rate (24.7%) compared with a normal population (47.8%), P less than 0.01. Since the survival rate in sick-sinus syndrome - with or without pacemaker - is not different to that of the normal population, improved quality of life by preventing symptoms should be balanced against the risk of pacemaker-produced complications when indications for pacemaker treatment are considered.
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http://dx.doi.org/10.1055/s-2008-1069551 | DOI Listing |
Comput Biol Med
January 2025
Emerging Technologies Research Lab (ETRL), College of Computer Science and Information Systems, Najran University, Najran, 61441, Saudi Arabia; Department of Computer Science, College of Computer Science and Information Systems, Najran University, Najran, 61441, Saudi Arabia. Electronic address:
- Brain tumors (BT), both benign and malignant, pose a substantial impact on human health and need precise and early detection for successful treatment. Analysing magnetic resonance imaging (MRI) image is a common method for BT diagnosis and segmentation, yet misdiagnoses yield effective medical responses, impacting patient survival rates. Recent technological advancements have popularized deep learning-based medical image analysis, leveraging transfer learning to reuse pre-trained models for various applications.
View Article and Find Full Text PDFBMC Pulm Med
January 2025
Department of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Background: In this study, we aimed to explore the association between baseline and early changes in the neutrophil-to-lymphocyte ratio (NLR) and the 30-day mortality rate in patients having anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis with interstitial lung disease (DM-ILD).
Methods: Overall, 263 patients with anti-MDA5 DM-ILD from four centers in China were analyzed. Multivariate logistic regression analysis was used to evaluate the impact of baseline NLR on the 30-day mortality rate in patients with anti-MDA5-positive DM-ILD.
Nat Med
January 2025
Vall d'Hebron Hospital Campus and Vall d'Hebron Institute of Oncology (VHIO), University of Vic - Central University of Catalonia, Barcelona, Spain.
Encorafenib + cetuximab (EC) is approved for previously treated BRAF V600E-mutant metastatic colorectal cancer (mCRC) based on the BEACON phase 3 study. Historically, first-line treatment of BRAF V600E-mutant mCRC with chemotherapy regimens has had limited efficacy. The phase 3 BREAKWATER study investigated EC+mFOLFOX6 versus standard of care (SOC) in patients with previously untreated BRAF V600E mCRC.
View Article and Find Full Text PDFSci Rep
January 2025
Division of Medical Oncology, Marmara University School of Medicine, Istanbul, Turkey.
Management of melanoma has changed significantly with the discovery of targeted therapies and immune checkpoint inhibitors (ICI). Our aim in the study is to determine which treatment alternatives, specifically dabrafenib plus trametinib and ICIs, are effective in adjuvant therapy and which treatment is effective as first-line metastatic therapy. This retrospective, multicenter study included 120 patients diagnosed with stage IIIB-IIID melanoma receiving both adjuvant and first-line metastatic treatment between 2007 and 2023.
View Article and Find Full Text PDFSci Rep
January 2025
Hangzhou Academy of Agricultural Sciences, Hangzhou, 310024, China.
Artificial fish nests are common tools in fisheries management, providing spawning grounds to enhance the size and diversity of fish populations. This study aimed to explore the effects of deployment locations on the reproductive efficiency and preferences of fish with adhesive and demersal eggs using artificial nests. Floating artificial nests were deployed in three regions (upstream, midstream, and downstream) of a reservoir in Zhejiang, China, at locations with three topographical types: steep slope (reservoir shore, slopes > 60°), gentle slope (reservoir shore, slopes < 30°), and confluence (middle thread of channel).
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