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| http://dx.doi.org/10.1136/hrt.49.2.199 | DOI Listing |
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Impairment of Microcirculation Parameters in Patients with a History of Diabetic Foot Ulcers.
Medicina (Kaunas)
December 2024
Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, CNRS UMR 5305, 69367 Lyon, France.
: According to the International Working Group on Diabetic Foot (IWGDF) risk classification, the estimated risk of developing a diabetic foot ulcer (DFU) is much higher in patients with a history of DFUs (Grade 3) compared to those with a peripheral neuropathy but without a history of DFUs (Grades 1 and 2). It has been suggested that microcirculation impairment is involved in DFU genesis and could be taken into account to refine the existing risk classification. The aim of this study was to evaluate microcirculation parameters in patients with diabetes according to their estimated DFU risk.
View Article and Find Full Text PDFHigh clinical burden of classical homocystinuria in the United States: a retrospective analysis.
Orphanet J Rare Dis
January 2025
Travere Therapeutics, Inc., San Diego, CA, USA.
Background: Classical homocystinuria (HCU) is a rare genetic metabolic disorder resulting in elevated homocysteine and methionine levels. The clinical characteristics and associated complications of HCU are well documented. However, there is limited published research on the clinical burden of patients with HCU, especially stratified by total homocysteine (tHcy) levels.
View Article and Find Full Text PDFPsychological process and risk factors of juvenile delinquency: Evidence from a qualitative analysis.
Child Abuse Negl
January 2025
Department of Psychology, Institute of Special Environmental Medicine, Nantong University, 9 Seyuan Road, Nantong 226019, Jiangsu Province, China.
Objectives: In recent years, juvenile delinquency has continued to occur at a high rate, necessitating attention to its criminal psychological process and underlying risk factors.
Methods: This study acquired psychological review data from 97 juvenile delinquents in China. Utilizing qualitative analysis, we delved into the psychological processes and risk factors that contribute to juvenile delinquency, aiming to reveal the psychological mechanisms involved.
Coats-Like reaction post-vitreoretinal surgery for PDR managed with laser photocoagulation and adjunctive intravitreal steroids- a case report.
BMC Ophthalmol
January 2025
Dept. of Retina and Vitreous, Narayana Nethralaya, #121/C, 1st R Block, Chord Road, Rajaji Nagar, Bengaluru, 560010, India.
Purpose: To report a rare case of a Coats-like response developing after vitreoretinal surgery for proliferative diabetic retinopathy (PDR) and its successful management with retinal laser photocoagulation and adjunctive intravitreal steroids.
Case Description: A 52-year-old woman with a five-year history of type 2 diabetes mellitus and hypertension presented with decreased vision in the left eye (counting fingers at 1 m). Examination revealed high-risk PDR in both eyes, with a subtotal macula-off combined retinal detachment in the left eye.
Art of TIL immunotherapy: SITC's perspective on demystifying a complex treatment.
J Immunother Cancer
January 2025
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
In a first for solid cancers, cellular immunotherapy has entered standard of care in the treatment of patients with metastatic melanoma. The infusion of autologous tumor-infiltrating T lymphocytes (TIL) is capable of mediating durable tumor regression and is now Food and Drug Administration-approved for patients with disease refractory to immune checkpoint inhibitors. Since the advent of chimeric antigen receptor (CAR) T cells for patients with hematological malignancies, a growing network of centers capable of delivering effector T cell products to patients has developed.
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