Various investigations for allergy were carried out on 57 nasal polyp patients. The majority of them (96.5%) showed positive responses to at least one of the methods used. The results suggest that allergy is a constant feature in the nasal polyp patients but that further investigation is needed before we can state that allergic manifestation contributes to polyp formation. It was also found in this study that 90% of the patients had definite pathological changes on their sinus x-rays. Sinus disease may be either predispose a patient to or result from nasal polyps.
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J Allergy Clin Immunol
January 2025
Division of Rhinology, Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine; Monell Chemical Senses Center, Philadelphia; PA; Corporal Michael J. Crescenz Veterans Administration Medical Center, Philadelphia, PA. Electronic address:
Acta Otolaryngol
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Brawijaya/Dr. Saiful Anwar General Hospital, Malang, Indonesia.
Background: Chronic Transforming Growth Factor Beta 1 (TGF-β1) plays a critical role in tissue remodelling and immunological modulation, which may contribute to the severity and recurrence of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Despite extensive research on CRSwNP, the exact role and pathological significance of TGF-β1 in CRSwNP remain poorly understood due to inconsistencies in study methodologies and findings.
Aims/objectives: To resolve discrepancies in the literature, this systematic review compares the levels of TGF-β1 in CRSwNP tissue to controls and Chronic Rhinosinusitis without Nasal Polyps (CRSsNP).
Cureus
January 2025
Department of Otolaryngology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, ROU.
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly affects patients' quality of life, impacting both physical and psychological well-being. This study investigated the potential role of resilience in coping with CRSwNP and its relationship to disease severity and cellular proliferation. Methodology Between July 1, 2021, and June 30, 2022, 30 patients diagnosed with CRSwNP were enrolled in a study at Cardiomed Hospital in Cluj-Napoca, Romania.
View Article and Find Full Text PDFFront Surg
January 2025
Department of Otolaryngology, Pei County People's Hospital, Xuzhou, Jiangsu, China.
Objective: This study was undertaken to assess the association between the likelihood of surgical recurrence and serum ECP and TIgE levels in chronic rhinosinusitis with nasal polyps (CRSwNP).
Methodology: Clinical information was gathered retrospectively from 166 cases of surgically treated CRSwNP as well as 60 cases of chronic rhinosinusitis without nasal polyps (CRSsNP). A comparative analysis on serum levels of total immunoglobulin E (TIgE) and eosinophil cationic protein (ECP) was carried out between the two groups.
Respir Res
January 2025
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China.
Background: Oxidative stress is key in inflammatory airway diseases. Heme oxygenase 1 (HMOX1) regulates oxidative stress, but its role in airway diseases needs exploration.
Methods: Differentially expressed genes (DEGs) between healthy nasal mucosa and chronic rhinosinusitis with nasal polyps (CRSwNP) were identified from Gene Expression Omnibus (GEO).
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