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Clear cell hidradenoma of the male breast: A case report and literature review.

Int J Surg Case Rep

January 2025

Department of Pathology, The First Affiliated Hospital of Zhejiang University School of Medicine, No.79 Qingchun Road, Hangzhou, Zhejiang 310003, China. Electronic address:

Introduction: Clear cell hidradenoma (CCH) is a rare type of benign breast tumor that may undergo malignant transformation in a few cases. It clinically manifests as a painless breast mass, and may include nipple discharge. Complete surgical excision with adequate safety margins is the primary treatment.

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Knowledge regarding the lesser common breast tumours, including malignant papillary neoplasms and glycogen-rich clear cell carcinoma, is limited. Overall, cases of papillary carcinoma of the breast fare better than invasive breast carcinoma, from the data available in literature. Glycogen-rich clear cell carcinoma is characterized by the presence of clear cells, having mostly a poorer prognosis.

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Article Synopsis
  • Invasive breast cancer is diverse, including various subtypes like glycogen-rich clear cell carcinoma, which is very rare and makes up about 3% of breast cancers.
  • Glycogen-rich clear cell carcinoma features distinct polygonal cells with clear cytoplasm full of glycogen and has an unclear prognosis, while the solid papillary pattern is a less common variant linked to less aggressive behavior if no invasion occurs.
  • This article discusses two new case studies of glycogen-rich clear cell carcinoma with solid papillary pattern, highlighting that these cases had a surprisingly good clinical outcome compared to typical cases, indicating a potentially better prognosis.
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[Alveolar soft part sarcoma in children: a clinicopathological study of 13 cases].

Zhonghua Bing Li Xue Za Zhi

February 2020

Department of Pathology, Children's Hospital of Hebei Province, Shijiazhuang 050031, China.

To investigate the clinicopathological manifestations, molecular genetic, diagnostic histology and differential diagnosis of alveolar soft part sarcoma (ASPS) in children. A total of 13 cases of ASPS diagnosed at Beijing Children's Hospital from August 2009 to November 2018 were collected. HE staining, histochemical staining for PAS and D-PAS, immunohistochemical (IHC) staining for TFE3, INI1 and CD68 and florescence in situ hybridization (FISH) for TFE3 gene translocation were performed.

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Background: Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. Majority of these tumors have microcystic appearance. Macrocystic and solid variants have also been described.

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