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Update on cancer screening in children with syndromes of bone lesions, hereditary leiomyoma and renal cell carcinoma syndrome, and other rare syndromes.
Clin Cancer Res
November 2024
National Cancer Institute, Bethesda, MD, United States.
The management of children with syndromes associated with an increased risk of benign and malignant neoplasms is a complex challenge for healthcare professionals. The 2023 AACR Childhood Cancer Predisposition Workshop provided updated consensus guidelines on cancer surveillance in these syndromes, aiming to improve early detection, intervention, and reduce morbidity associated with such neoplasms. In this paper, we review several of the rare conditions discussed in this workshop.
View Article and Find Full Text PDFUnveiling the advantages of laparoscopic myomectomy: A comprehensive systematic review and meta-analysis of outcomes and complications compared with traditional open surgery.
Eur J Obstet Gynecol Reprod Biol
December 2024
Unit of Gynaecology and Obstetrics, Department of Human Pathology of Adult and Childhood 'G. Barresi', University of Messina, Messina, Italy.
Article Synopsis
- The study compares laparoscopic myomectomy (LM) and open myomectomy (OM) by analyzing postoperative complications, blood loss, operative time, and length of hospital stay using the Clavien-Dindo classification.
- LM showed significantly lower rates of overall postoperative complications and mean blood loss compared to OM, with an associated statistically significant shorter hospital stay.
- Additionally, while operative times were similar, the findings indicate a clear advantage for LM in terms of patient recovery and safety.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Paediatric diffuse oesophageal leiomyomatosis with Alport syndrome.
BMJ Case Rep
August 2024
Department of Paediatric Surgery, Institute Of Systems Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Diffuse oesophageal leiomyomatosis is a rare benign disease in the paediatric population. This report highlights a recent clinical case, together with a narrative review of current world literature.An early middle childhood girl with recurrent lower respiratory tract infections for 2 years was noted to have a retrocardiac lesion on chest X-ray, later confirmed to be an oesophageal mass on CT imaging.
View Article and Find Full Text PDFImaging of pediatric gastrointestinal tumors: A tertiary center experience over 19 years.
Eur J Radiol
June 2024
Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, M5G 1X8, Canada; Department of Medical Imaging, University of Toronto, Canada. Electronic address:
Purpose: Gastrointestinal tract (GIT) tumors in children are rare and there is a scarcity of data on their imaging features. The purpose of this study was to determine thefrequency of various GIT tumor types in children and to identify key imaging characteristics.
Methods: This retrospective, single-center study was approved by the local ethics committee.
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