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Melatonin Overexpression in the Management of Alzheimer's Disease: Therapeutic Exploration.
Curr Top Med Chem
January 2025
Graphic Era (Deemed to be University), Clement Town Dehradun, India.
Alzheimer's Disease (AD), a progressive neurodegenerative disorder, is characterized by the accumulation of neurofibrillary tangles and β-amyloid plaques, leading to a decline in cognitive function. AD is characterized by tau protein hyperphosphorylation and extracellular β-amyloid accumulation. Even after much research, there are still no proven cures for AD.
View Article and Find Full Text PDFResponse to the SAMHSA Clinical Advisory: Considerations for Genetic Testing in the Assessment of Substance Use Disorder Risk.
Subst Abuse Rehabil
January 2025
Department of Psychiatry, Texas Tech University Health Sciences, School of Medicine, Midland, TX, USA.
Under-representation of older Indian persons with cancer in clinical trials.
BMJ Oncol
August 2024
Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Objective: Older patients with cancer have traditionally been under-represented in global clinical trials. There are no data from India regarding this issue.
Methods And Analysis: This was a retrospective analysis done at our institute on interventional studies conducted between 2003 and 2023 in adult patients with malignancies.
In perennial allergic rhinitis, RQLQ is improved similarly by Azelastine 0.15 and mometasone furoate.
World Allergy Organ J
January 2025
Allergy & Asthma Solutions, Coto de Caza, CA, USA.
Unlabelled: Some double-blind, placebo-controlled trials have shown that Azelastine (Aze) high dose (0.15%) was effective in seasonal (SAR) and perennial allergic rhinitis (PAR). However, there was no long-term comparison between Aze 0.
View Article and Find Full Text PDFProtective effect and mechanism of Sufentanil on acute lung injury in septic mice.
Front Pharmacol
January 2025
Emergency Surgery Department, Yantai Affiliate Hospital of Binzhou Medical University, Yantai, Shandong, China.
This study was designed to investigate the protective effect and mechanism of Sufentanil on acute lung injury in septic mice based on network pharmacology and animal experiments, and to provide new ideas for clinical treatment. To this end, a protein-protein interaction (PPI) network for common targets was first constructed with Swiss Target Prediction Database, GeneCards Database, Draw Venn Diagram Software, STRING 11.5 Database, Cytoscape 3.
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