Matrix antigens in allografts. II. The cell-mediated response.

The cell-mediated response of link proteins (LP) and proteoglycan monomer (PG), the matrix antigens of articular cartilage, was investigated in the late rejections of joint allografts in dogs. Cell-mediated immunity was present as determined by the Macrophage Inhibition Test and by skin sensitivity, which was present at 26 and 52 weeks after allografting. The Migration Inhibition was 70% at 12 weeks, and 50% at 26 and 52 weeks after allografting. Skin sensitivity was present after these intervals. The synovium was hypercellular, had the appearance of a pannus, and invaded and destroyed the graft.