AI Article Synopsis
- A study on 24 rats with mammary adenocarcinomas demonstrated that nuclear magnetic resonance (NMR) imaging effectively detected all tumors without false positives in control rats.
- The T1 and T2 relaxation times for the tumors were similar to those of muscle and fat, but the unique combination allowed for accurate differentiation between tumors and surrounding tissues.
- The findings support previous research showing that NMR imaging is a highly sensitive tool for detecting tumors, although T1 and T2 times alone are not definitive indicators of cancer.
Article Abstract
A study of 24 rats implanted in the hind leg with mammary adenocarcinomas and five sham-implanted rats, followed from the second to the eight week postimplantation, showed nuclear magnetic resonance imaging capable of detecting all the tumors without yielding any false-positives in the control rats. The T1 relaxation time of tumors overlapped that of muscle, and the T2 times overlapped fat, but the combination was unique when comparing tumors to muscle and fat. Necrotic regions of the tumor and the bladder contents tended to have very long T1 and T2 relaxation times. The difference in relaxation time between tumors and muscle could be accounted for in terms of water content, which was approximately 8% higher for the tumors. The study corroborates data from previous studies indicating that NMR imaging is a highly sensitive modality, although T1 and T2 times are not exclusive indicators of malignancy.
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| http://dx.doi.org/10.1002/1097-0142(19830201)51:3<433::aid-cncr2820510314>3.0.co;2-u | DOI Listing |
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