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The IL-6 axis in vascular inflammation: effects of IL-6 receptor blockade on vascular lesions from patients with giant-cell arteritis.
Ann Rheum Dis
March 2025
Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic (member of European Reference Network [ERN]-for rare diseases RITA), University of Barcelona, Centre de Recerca biomèdica (CRB)-CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:
Objectives: Blocking interleukin (IL)-6-receptor with tocilizumab has been a major advance in the treatment of giant-cell arteritis (GCA), supporting a crucial role of IL-6 receptor signalling. However, nearly half of the patients are not able to maintain glucocorticoid- free remission with tocilizumab. The impact of tocilizumab on vascular lesions of GCA is largely unknown since conflicting results have been obtained by imaging.
View Article and Find Full Text PDFTreatment indications for antidepressants prescribed in primary health care facilities in Beijing, China.
Int Psychogeriatr
March 2025
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; International Research Center for Medicinal Administration, Peking University, Beijing 100191, China.
To examine the prevalence of treatment indications for antidepressants and assessed temporal trends in antidepressant prescribing for depression among adult patients in primary health care facilities (PHFs) in China. Descriptive study of antidepressant prescriptions written by primary care physicians. Setting participants: Patients aged 18 years and above in 67 PHFs in Dongcheng district in Beijing between 1 January 2014 and 31 December 2022.
View Article and Find Full Text PDFUnveiling the hemispheric specialization of language: Organization and neuroplasticity.
Handb Clin Neurol
March 2025
Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, LPNC, Grenoble, France. Electronic address:
The advancements in understanding hemispheric specialization of language (HSL) have been following two primary avenues: the development of neuroimaging techniques and the study of its reorganizations in patients with various neuropathologic conditions. Hence, the objectives of this chapter are twofold. First, to provide an overview of the key neuroimaging techniques employed to investigate HSL, along with the notable findings derived from them in the healthy population.
View Article and Find Full Text PDFBrain asymmetries in figurative language comprehension.
Handb Clin Neurol
March 2025
CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy. Electronic address:
This chapter reviews the literature concerning the neural basis of three types of figurative expressions, namely, idioms, metaphors, and irony. Besides these three forms of language, which are the most investigated, many other types exist, differing in their linguistic structure and, consequently, in the corresponding comprehension processes. After defining the most common figurative expressions and showing how they differ in terms of linguistic properties, the chapter presents early studies that focused on the role of the right hemisphere (RH) in figurative language comprehension in general, without a clear distinction among different forms.
View Article and Find Full Text PDFGlobal Incidence, Risk Factors, and Temporal Trends of Adrenal Cancer: a systematic analysis of cancer registries.
Endocr Pract
March 2025
The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China; Centre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Global Health, School of Public Health, Peking University, Beijing, China. Electronic address:
Objectives: Adrenal gland cancer (AGC) is a rare cancer with a poor prognosis. Studies on this cancer have been limited. This study, for the first time, aims to analyse the global disease burden and trends of adrenal gland cancer in country level and examine lifestyle and socioeconomic risk factors to generate hypotheses.
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