Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00007890-198211000-00017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Hematopoietic stem cell transplantation (HCT) is a potentially life-saving therapy for individuals with blood diseases, but involves a challenging recovery process that requires dedicated caregivers. The complex interplay between emotional distress, care partner (or unpaid caregiver) burden, and treatment outcomes necessitates comprehensive physiological and psychological measurements to fully understand these dynamics.
Findings: We collected longitudinal data from 166 HCT caregiver-patient dyads over 120 days post-transplant as part of a randomized controlled trial ( NCT04094844 ).
Association between positive affect, flourishing, quality of life, and psychological distress in allogeneic hematopoietic stem cell transplantation.
J Psychosoc Oncol
October 2024
Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- - The study investigates how positive psychological well-being (PPWB) relates to mood and quality of life in people who have undergone hematopoietic stem cell transplantation (HSCT), using data from 158 recipients.
- - Results indicate that older age, greater social support, and certain health conditions correspond with higher PPWB levels, which are linked to improved quality of life and reduced symptoms of PTSD, anxiety, and depression.
- - The researchers suggest that future studies should explore these associations over time to better understand how PPWB affects HSCT recovery and to develop targeted interventions for improving patient outcomes.
Biobehavioral mechanisms underlying symptoms in cancer patients with chronic graft-versus-host disease.
Brain Behav Immun
January 2025
Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53719, USA; Carbone Cancer Center, University of Wisconsin- Madison, Madison, WI, 53792, USA. Electronic address:
Chronic graft-versus-host disease (cGVHD) is a complication of allogeneic hematopoietic cell transplant (HCT) and is associated with morbidity and high symptom burden. This study evaluated two biobehavioral mechanisms, inflammation and circadian rest-activity rhythms, that may underly commonly reported psychological and physical symptoms in cGVHD patients. Adults with cGVHD (N=57) wore a wrist actigraph for 7 days, provided a blood sample, and completed patient-reported outcome (PRO) measures.
View Article and Find Full Text PDFTripartite prehabilitation of patients with acute myeloid leukaemia and high-risk myelodysplastic syndromes during intensive chemotherapy before allogeneic haematopoietic stem cell transplantation (COHABILIT): protocol for an innovating prospective multicentre study.
BMJ Open
March 2024
Department of Oncology, Paoli-Calmettes Institute, Marseille, France.
Objectives: Acute myeloid leukaemia (AML) and high-risk myelodysplastic syndromes (MDS) are often treated with intensive chemotherapy followed by allogeneic haematopoietic stem cell transplantation (allo-HSCT). The pretransplant treatment results in a general deterioration of the patient's health and quality of life. Furthermore, allo-HSCT can be responsible for significant toxicity with risks of graft-versus-host disease (GvHD).
View Article and Find Full Text PDFGroup Coping Intervention in Patients With Chronic Graft-Versus-Host Disease: A Pilot Randomized Clinical Trial.
J Natl Compr Canc Netw
February 2024
1Massachusetts General Hospital, Boston, Massachusetts.
Background: More than half the long-term survivors of allogeneic hematopoietic cell transplantation develop chronic graft-versus-host disease (GVHD), a debilitating inflammatory syndrome. Supportive interventions to assist survivors in coping with chronic GVHD are critically needed.
Patients And Methods: We conducted a pilot randomized clinical trial of a multidisciplinary group intervention (Horizons Program; n=39) versus minimally enhanced usual care (n=41) for patients with moderate or severe chronic GVHD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!