Eight patients with sexual impotence, fertile and clinically normal, average age of 41, were given TU orally for 46 days, in a dose of 120 mg/day. The mean (+/- SE) plasma FSH, LH and testosterone levels were significantly lower than in a group of 20 healthy adult men, average age 36. In the course of treatment there were no significant changes of mean serum FSH and LH concentrations, while circulating testosterone levels rose significantly to normal levels throughout the whole study. Almost all patients reported a marked increase in sexual and mental activities. The identical pattern as in hypogonadotrophic hypogonadal patients is considered and a possible hypothalamo-hypophyseal deficiency in the pathogenesis of sexual impotence in all 8 subjects is envisaged.
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