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Ceftazidime-avibactam for the treatment of febrile neutropenia in HSCT recipients and acute leukemia patients post induction chemotherapy.
Sci Rep
December 2024
American University of Beirut, Cairo Street, Riad El Solh, PO Box 11-0236/11D, Beirut, 1107 2020, Lebanon.
Febrile neutropenia is a major complication in patients with acute leukemia or those undergoing hematopoietic stem cell transplantation (HSCT). Understanding patient characteristics and susceptibility patterns in febrile neutropenia is essential for appropriate antimicrobial therapy. First-line agents should have Pseudomonas aeruginosa coverage, but with the increase in multi-drug resistant organisms, ceftazidime-avibactam has emerged as a new therapeutic option.
View Article and Find Full Text PDFRisk factors and outcome of Pseudomonas aeruginosa bloodstream infections (PABSI) in hematological patients: a single center retrospective cohort study.
Infection
December 2024
Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Purpose: Bloodstream infections caused by Pseudomonas aeruginosa (PABSI) in hematological patients are associated with high morbidity and mortality. We investigated the epidemiology, risk factors, and outcomes of PABSI at our center.
Methods: All adult hematological patients with PABSI between January 2013 and July 2023 were included.
A case report of severe drug-induced immune hemolytic anemia caused by piperacillin.
Front Immunol
November 2024
Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Piperacillin is a beta-lactamase inhibitor frequently used in the treatment of urinary tract infections. It is a broad-spectrum antibiotic with strong antibacterial action against and , especially extended-spectrum beta-lactamase-producing Enterobacteria and . Side effects of piperacillin include allergic reactions, rashes such as urticaria, leukopenia, interstitial nephritis, asthma attacks, serological reactions, candida infection, and bleeding with more severe reactions resulting in anaphylactic shock.
View Article and Find Full Text PDFCurrent practice of screening and antimicrobial prophylaxis to prevent Gram-negative bacterial infection in high-risk haematology patients: results from a pan-European survey.
Ther Adv Infect Dis
October 2024
Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Article Synopsis
- - The study examines the use of antimicrobial prophylaxis (AMP) in haematological patients, particularly those at high risk for bacterial infections due to prolonged neutropenia after chemotherapy, amidst the rise of multi-drug resistant Gram-negative bacteria (MDR-GNB).
- - A survey conducted with 120 haematology centers across 28 European countries revealed that most centers (86.7%) routinely screen for MDR-GNB, with a significant number (39.2%) using fluoroquinolones for prophylaxis.
- - While bloodstream infections (BSI) rates were slightly lower in patients receiving AMP, the overall increase in MDR-GNB infections highlights the need for improved antimicrobial stewardship and tailored prophylactic strategies.
Phage-Antibiotic Combination Therapy against Recurrent Septicaemia in a Patient with an Arterial Stent.
Antibiotics (Basel)
September 2024
Human Microbiome Research Program, Research Programs Unit and Medicum, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Intravascular stent infections are often associated with high risks of morbidity and mortality. We report here a case of a patient with an arterial stent and recurrent septicaemias successfully treated with phage-meropenem combination therapy. A 75-year-old female with arteriosclerosis and comorbidities went through a femoropopliteal bypass with prosthesis in the right inguinal area.
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