The effects of neonatally administered steroids on the sensitivity of the mammary gland to tumour induction by 7, 12-dimethylbenz (alpha) anthracene was studied as a model for delayed (de) differentiating effects of steroid hormones. Immediately after birth male and female rats were gonadectomized and treated with testosterone, oestradiol or oil. Control animals were left intact. On day 45 all the gonadectomized animals and some of the control animals received an implant which delivered continuous low levels of oestradiol. The carcinogen was administered on day 55. The administration of an oestradiol implant, which increased prolactin levels in all animals, markedly reduced tumour incidence in intact female rats and increased tumour incidence in intact male rats. Neonatal administration of testosterone or oestradiol did not significantly influence tumour incidence, histopathology or oestradiol responsiveness in neonatally gonadectomized rats but tended to decrease tumour animals suggests that the effects observed by other authors in intact rats are mediated by changes in gonadal secretions. It is concluded that the hormonal environment during and after tumour induction plays a major role in the development of 7, 12-dimethylbenz (alpha) anthracene-induced mammary carcinomas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1677/joe.0.0950357 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Combining Water-Soluble Porphyrin and Phthalocyanine Photosensitizers With Doxorubicin Improves the Efficacy of Chemo-Photodynamic Therapy Against DMBA-Induced Breast Carcinoma.
Chem Biodivers
December 2024
Institute of Basic and Applied Sciences, Egypt-Japan University of Science and Technology, New Borg El Arab, Alexandria, Egypt.
Breast cancer ranks as the second most widespread form of cancer globally. Currently, combination therapy is being actively employed in clinical practice to augment the efficiency of anticancer treatment. Hence, the objective of this study was to assess the therapeutic efficacy of a combination of femtosecond laser-based photodynamic therapy (PDT) utilizing two distinct photosensitizers (PSs), zinc phthalocyanine tetrasulfonate (ZnPcS) and α,β,χ,δ porphyrin-Tetrakis (1-methylpyridinium-4-yl) p-Toluenesulfonate porphyrin (TMPyP) in conjunction with doxorubicin chemotherapeutic agent, on mammary carcinomas experimentally induced in female mice using 7,12-dimethylbenz[a] anthracene (DMBA).
View Article and Find Full Text PDFInvestigation of the Relationship Between Brown HT Dye Exposure and Mammary Tumor Development in Female Rats: An Assessment of the Potential Risk of Breast Cancer.
Cureus
November 2024
Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, BGD.
Article Synopsis
- * Female Long-Evans rats were divided into groups to assess the effects of E155 on tumor development, with some receiving the dye in various doses over 40 weeks compared to control groups.
- * Results showed that higher E155 doses led to significant weight loss, renal impairment, liver dysfunction, and an increased incidence of mammary tumors, suggesting that prolonged exposure could heighten breast cancer risk.
A novel quinazoline derivative exhibits potent anticancer cytotoxicity via apoptosis and inhibition of angiogenesis in DMBA-induced mammary gland carcinoma.
J Biochem Mol Toxicol
November 2024
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India.
Mammary gland carcinoma is one of the most prevalent and deadly diseases among women globally. It is a type of solid malignant tumor. In this malignant tumor, the microenvironment becomes hypoxic in rapidly proliferating cancer cells.
View Article and Find Full Text PDFEfficacy of Extract against 7,12-Dimethylbenz[]anthracene-Induced Cancer in Mice.
J Microbiol Biotechnol
November 2024
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam.
Article Synopsis
- Blume tea, a traditional Vietnamese medicine, has shown potential in treating various health issues and possesses diverse pharmacological properties, although its anticancer effects were previously unclear.
- Recent studies indicated that extracts from J. subtriplinerve, specifically the ethyl acetate fraction, demonstrated significant anti-proliferative effects on breast cancer cells while other fractions did not show efficacy.
- In mouse models, the ethyl acetate fraction reduced tumor incidence and mortality when administered, suggesting that Blume tea could be a safe and effective chemopreventive option against breast cancer.
Pre-clinical Evaluation of Karanjin Against DMBA-Induced Breast Cancer in Female Sprague-Dawley Rats Through Modulation of SMAR1 and CDP/CUx genes.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, Changa-388421, Anand, Gujarat, India.
Purpose: To investigate the chemoprotective potential of karanjin against 7,12-dimethylbenz(α)anthracene (DMBA)-induced breast cancer.
Methodology: Thirty-six female rats were utilized for the study. Breast cancer was induced through a subcutaneous injection of 35 mg/kg DMBA.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!