AI Article Synopsis
- Scientists isolated phages targeting Bacillus anthracis from lysates of Bacillus cereus strains that produce megacin A.
- The new phages exhibited similarities to the previously identified anthrax-specific phage AP 50 in terms of structure, host range, and sensitivity to various chemicals.
- DNA analysis confirmed the unique nature of AP 50, indicating that it and similar phages form a distinct group affecting Bacillus strains.
Article Abstract
Phages exerting a specific action on Bacillus anthracis were isolated from mitomycin C-induced concentrated lysates of 5 Bacillus cereus strains producing megacin A (phospholipase A). In electron micrographs the phages closely resembled the anthrax-specific, lipid containing phage AP 50 isolated earlier from soil sample. The phages were similar to AP 50 also in their antigenic and chemical structure, host range and sensitivity to organic solvents, detergents and caesium chloride. The DNA character of AP 50 nucleic acid was shown by agarose gel electrophoresis. AP 50 and related phages seem to represent a separate group of phages acting on Bacillus strains.
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