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Nursing management of a patient with central retinal artery occlusion after percutaneous coronary intervention: a case report.
AME Case Rep
November 2024
Cardiology Department II Ward I, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Central retinal artery occlusion (CRAO) is a rare but critical complication that might appear after percutaneous coronary intervention (PCI) with a high risk of blindness. The report on the nursing management of CRAO patients after PCI is rare.
Case Description: This patient is a 50-year-old female patient who was admitted to the Cardiovascular Department with repeated chest tightness.
Zolmitriptan niosomal transdermal patches: combating migraine via epigenetic and endocannabinoid pathways and reversal of migraine hypercoagulability.
Drug Deliv Transl Res
November 2024
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, 21648, Egypt.
Conventional zolmitriptan (ZOL) has limited oral bioavailability, many adverse effects, and poor membrane penetrability that negatively influences its accessibility to its 5-HT receptor binding pocket, located transmemberanous. This work aimed at preparing transdermal ZOL-nanoformulation (niosomes) to surpass these limitations and to explore novel antimigraine mechanisms for ZOL via modulation of the epigenetically-altered chronification genes (RAMP-1, NPTX-2) or microRNAs and affecting the endocannabinoid CB-1/MAPK pathway. The prepared ZOL niosomes (F) exhibited %EE of 57.
View Article and Find Full Text PDFMaking Sense of Topical Pain Relief Options: Comparing Topical Analgesics in Efficacy and Safety.
Sports Health
October 2024
Department of Community Health and Family Medicine, University of Florida, Gainesville, Florida.
Context: In patients with musculoskeletal (MSK) conditions, pain is the leading contributor to disability and significantly limits mobility and dexterity. This narrative review describes the efficacy and safety of topical analgesics in common use today.
Evidence Acquisition: Secondary literature gained via a literature search using PubMed.
Transdermal Drug Delivery Systems (TDDS): Recent Advances and Failure Modes.
Mol Pharm
November 2024
Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, Queensland 4102, Australia.
Transdermal drug delivery systems (TDDS), commonly refered to as "patches", present a nonintrusive technique to provide medication without the need for invasive procedures. These products adhere to the skin and gradually release a specific dosage of medicine at a defined rate into the bloodstream. Compared with other methods of drug delivery, TDDS offer benefits such as reduced invasiveness, convenience for patients, and avoidance of the metabolic processes that occur when drugs are orally consumed.
View Article and Find Full Text PDFThe effect of nitroglycerin treatment on cerebral ischaemia: A systematic review and meta-analysis of animal studies.
Nitric Oxide
October 2024
School of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, Australia; Heart and Stroke Programme, Hunter Medical Research Institute, Newcastle, Australia. Electronic address:
Background: Nitroglycerin has been of considerable interest as a treatment for ischaemic stroke. Recent clinical trials with nitroglycerin transdermal patches during the acute phase of stroke failed to improve functional outcomes. Systematic review and meta-analysis of the effectiveness of nitroglycerin in preclinical models of ischaemic stroke has not previously been reported, despite several clinical trials.
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