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[Serum metabolomics reveals effects of standard decoction and formula granules of Paeoniae Radix Rubra on rat model of heat toxin and blood stasis].
Zhongguo Zhong Yao Za Zhi
October 2024
Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine Guangzhou 510095, China Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Research and Development Guangzhou 510095, China.
This study aims to compare the effects and mechanisms of the standard decoction and formula granules of Paeoniae Radix Rubra in regulating the metabolism in the rat model of heat toxin and blood stasis. SD rats were randomized into control, model, standard decoction, and formula granules groups. After 14 days of administration, the rats in the latter three groups were subjected to subcutaneous injection with carrageenan and intraperitoneal injection with bacterial lipopolysaccharide for the modeling of heat toxin and blood stasis.
View Article and Find Full Text PDFPlatelet aggregation responses to Typhimurium are determined by host anti- antibody levels.
Platelets
December 2024
Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Invasive non-typhoidal infections are responsible for >75 000 deaths/year and >500 000 cases/year globally. Seventy-five percent of these cases occur in Sub-Saharan Africa, an increasing number of which are from multi-drug resistant strains. Interactions between bacteria and platelets can lead to thrombus formation, which can be beneficial for control of infection (immunothrombosis), or harmful through uncontrolled inflammation and organ damage (thromboinflammation).
View Article and Find Full Text PDFEffects of exercise on cAMP-mediated platelet inhibition in young women: a pilot study.
Eur J Appl Physiol
December 2024
UCD School of Medicine, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
Purpose: Exercise has been shown to reduce platelet reactivity and increase platelet sensitivity to prostacyclin, an endothelium-derived inhibitor of platelet activation, in middle-aged men and women. It is currently unknown if these beneficial effects can also be observed in young women and the intracellular mechanisms involved have not been identified. In this study, the feasibility of detecting changes in platelet reactivity, prostacyclin sensitivity and cAMP signalling were tested.
View Article and Find Full Text PDF[Antithrombotic Action of Alcohol in Relation to Platelet Function].
Nihon Eiseigaku Zasshi
December 2024
Department of Preventive Medicine, Hyogo Medical University Faculty of Medicine.
The relationship between alcohol consumption and incident ischemic heart disease and stroke is characterized by a J- or U-shape. This denotes that light drinking has a preventive effect on cardiovascular diseases. Effects of alcohol drinking on lipid metabolism including an increase in HDL cholesterol concentration and a decrease in LDL cholesterol concentration are the main reasons for the anti-atherosclerotic action of alcohol.
View Article and Find Full Text PDFHuman Disabled-2 regulates thromboxane A signaling for efficient hemostasis in thrombocytopenia.
Nat Commun
November 2024
Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan, Republic of China.
Article Synopsis
- Understanding platelet protein functions improves diagnosis and treatment of platelet disorders.
- Researchers used human Disabled-2 knock-in (hDAB2-KI) mice to study how hDab2 regulates platelet function and bleeding in cases of low platelet counts (thrombocytopenia).
- Findings show that hDab2 enhances certain platelet responses, leading to reduced bleeding time and indicating its significant role in managing bleeding severity related to thrombocytopenia.
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