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Inhibition of noradrenergic and corticotrophin-releasing factor systems: Effects on enhancement of memory consolidation by unconditioned and conditioned heroin withdrawal.
Neuropharmacology
May 2022
Department of Psychology & Collaborative Neuroscience Program, Guelph, Ontario, Canada. Electronic address:
Article Synopsis
- The study investigates how unconditioned and conditioned opioid withdrawal affects memory consolidation by focusing on noradrenaline (NA) and corticotrophin-releasing factor (CRF) systems.
- Male rats underwent heroin treatment and withdrawal to analyze memory changes during spontaneous object recognition tasks, using drugs like naloxone, lofexidine, and antalarmin.
- Results indicate that both pharmacological (naloxone) and psychological (contextual exposure) withdrawal enhance memory by activating NA and CRF systems, with lofexidine and antalarmin blocking this enhancement.
Differential effects of acute and chronic treatment with the α2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys.
Drug Alcohol Depend
December 2013
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA. Electronic address:
Background: Lofexidine, an α2-adrenergic agonist, is being investigated as a treatment for reducing opioid withdrawal symptoms and blocking stress-induced relapse to cocaine taking. Opioid abusers are often polydrug abusers and cocaine is one frequent drug of choice. However, relatively little is known about lofexidine interactions with cocaine.
View Article and Find Full Text PDFNorepinephrine and stimulant addiction.
Addict Biol
April 2009
Department of Psychiatry, School of Medicine, Yale University, USA and VA Connecticut Healthcare System, USA.
No pharmacotherapies are approved for stimulant use disorders, which are an important public health problem. Stimulants increase synaptic levels of the monoamines dopamine (DA), serotonin and norepinephrine (NE). Stimulant reward is attributable mostly to increased DA in the reward circuitry, although DA stimulation alone cannot explain the rewarding effects of stimulants.
View Article and Find Full Text PDFAlpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking.
Neuropsychopharmacology
August 2000
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Quebec, Montreal, Canada.
The alpha-2 adrenergic receptor agonists, clonidine, lofexidine and guanabenz, blocked stress- but not cocaine-induced reinstatement of cocaine seeking at doses that suppressed footshock-induced release of noradrenaline in prefrontal cortex and amygdala. Rats were trained to self-administer cocaine (0.5 mg/kg/infusion, i.
View Article and Find Full Text PDFEffects of lofexidine, an alpha 2-adrenoreceptor agonist, on ocular blood flow and ion transport of rabbit iris-ciliary body.
J Ocul Pharmacol
November 1992
Department of Pharmacology, Texas College of Osteopathic Medicine, University of North Texas, Fort Worth.
The effect of topical unilateral application of lofexidine, an alpha 2-agonist, on ocular regional blood flow was tested in anesthetized rabbits using radiolabeled microspheres. A significant reduction in blood flow was found only in the ciliary body of the treated eye at 1 hr after lofexidine treatment. However, the IOP of both eyes was decreased significantly at 30 and 60 min post lofexidine treatment.
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