Verruciform xanthoma is an unusual lesion that was initially reported in 1971. Clinically, it is a verrucous, vascular, epithelial plaque or papillomatous growth commonly found on oral or mucosal tissues. Histologically, it is characterized by a verruciform epithelium with abundant parakeratosis and by foam cells occupying the vascularized dermal papillae. This is the second extramucosal verruciform xanthoma reported. Our patient had several unique features. She is the youngest patient described to date, her lesion is the largest reported, and the lesion occurred in an epithelial nevus-type eruption of a phocomelic extremity. Light and electron microscopic studies disclosed abnormal keratinization, mast cell proliferation, and the previously described foam cells. We believe that the verruciform xanthoma in our patient represents part of a reaction to the epithelial nevus occurring in association with a developmental anomaly.
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Oral Verruciform Xanthoma of the Lower Lip: A Rare Entity.
Cureus
November 2024
Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- Oral verruciform xanthoma (OVX) is a rare, benign oral lesion that can resemble other common growths and has only a few documented cases.
- It typically appears in areas like the masticatory mucosa, with its exact cause still uncertain, but it's thought to arise from monocyte/macrophage lineage.
- In a reported case, a 20-year-old male had a keratotic growth on his lower lip that was diagnosed as OVX through histopathology and immunohistochemistry; it was successfully surgically excised with no recurrence afterward.
Verruciform Xanthoma Presenting Within an Ear Piercing.
Indian J Dermatol
October 2024
Department of Dermatology, The Philadelphia College of Osteopathic Medicine, Philadelphia, PA.
Verruciform xanthomas are rare lesions affecting 0.025-0.5% of the population.
View Article and Find Full Text PDF[Not Available].
Swiss Dent J
June 2024
Klinik für Oral Health & Medicine, Universitäres Zentrum für Zahnmedizin Basel UZB, Uni-versität Basel, Schweiz.
Article Synopsis
- * Its exact cause is unknown, and while it can occur in healthy people, it has also been seen in those with autoimmune conditions or chronic graft-versus-host disease (GvHD).
- * The recommended treatment is to surgically remove the lesion, as demonstrated in a case involving a successful excision from a 56-year-old patient with GvHD after stem cell transplantation for Non-Hodgkin lymphoma.
Article Synopsis
- The text discusses a rare case of verruciform xanthoma of the penis in a male patient who also has genital lichen sclerosus.
- This is only the second documented case of this particular condition.
- The authors recommend that when diagnosing verruciform xanthoma, healthcare providers should closely check for signs of lichen sclerosus, as these signs can be subtle.
Oral verruciform xanthomas mimicking potentially malignant disorders.
J Clin Exp Dent
April 2024
DDS, MSc, PhD. Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
Article Synopsis
- Verruciform xanthoma is a rare reactive lesion that typically appears in the skin but can also occur in the oral cavity, where it may be mistaken for leukoplakia.
- The text describes two cases of 30-year-old individuals with white plaques on the tongue and floor of the mouth, which were confirmed to be oral verruciform xanthomas through histopathological analysis.
- It's important for dental professionals to consider verruciform xanthoma in their differential diagnosis for potential oral cancer since it can appear in high-risk areas, with histopathological analysis being the most reliable method for diagnosis.
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