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Rituximab Treatment in Adult Patients With Idiopathic Inflammatory Myositis: A Systematic Review and Meta-analysis.
J Clin Rheumatol
January 2025
From the Division of Rheumatology, University of Florida College of Medicine, Jacksonville, FL.
Article Synopsis
- This systematic review and meta-analysis investigates the effectiveness and safety of rituximab (RTX) for treating idiopathic inflammatory myositis (IIM) by analyzing multiple studies through a systematic search of PubMed and Embase.
- Seventeen studies involving 362 patients were included, revealing an overall response rate of 70%, with complete remission in 13% and partial response in 48%, indicating significant variation among different myositis types.
- While RTX shows promise for IIM treatment, the notable side effects, including infusion reactions and infections, underscore the necessity for careful patient monitoring and further controlled trials to better understand long-term effects and establish treatment protocols.
Sheep abortions associated with Neospora caninum and Toxoplasma gondii infections in multiple flocks from Southern Brazil.
Vet Res Commun
August 2024
Laboratório de Patologia Animal, Centro de Ciências Agroveterinárias (CAV), Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões, 2090, Conta Dinheiro, Lages, SC, 88520-000, Brasil.
Neosporosis and toxoplasmosis are important parasitic causes of abortions in small ruminants. This study verified the occurrence of these diseases in sheep fetuses from Santa Catarina State, Southern Brazil from 2015 to 2022. Sheep fetuses were necropsied with organ sampling for histopathology, and polymerase chain reaction (PCR) for Neospora caninum and Toxoplasma gondii using the Nc5 and SAG2 targets, respectively, in frozen brain tissue.
View Article and Find Full Text PDFAcute leg pain and weakness in pregnancy: A new diagnosis of myotonic dystrophy.
Obstet Med
December 2023
Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia.
We present a unique case of a 44-year-old woman who presented at 29 weeks' gestation with proximal limb pain and elevated creatine kinase. This occurred in the background of premature cataracts, atrial fibrillation and abnormal liver function. Clinical, pathological and neurodiagnostic findings supported a diagnosis of myotonic dystrophy, confirmed by genetic testing which revealed dystrophia myotonica protein kinase gene expansion.
View Article and Find Full Text PDFNew onset MDA-5 positive dermatomyositis and massive perivillous fibrin deposition in third trimester of pregnancy: A case report.
J Obstet Gynaecol Res
June 2023
Dermatology Department, Western Health, Melbourne, Victoria, Australia.
We report a case of a 42-year-old woman (Gravida 1, Para 1) who presented in her third trimester of pregnancy with a photo distributed eruption and arthralgias and was subsequently diagnosed with dermatomyositis. She had an emergency Caesarean section at 34 weeks plus 6 days gestation due to decreased fetal movements and non-reassuring fetal heart rate. Her placenta was sent for histopathology and showed features of massive perivillous fibrin deposition.
View Article and Find Full Text PDFMicrocephaly and hydrocephalus in a sheep fetus infected with Neospora caninum in Southern Brazil - Short communication.
Acta Vet Hung
September 2022
1 Laboratório de Patologia Animal, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina - Av. Luís de Camões, 2090, Conta Dinheiro, Lages, Santa Catarina, Brazil.
A case of non-communicating hydrocephalus and microcephaly in a sheep fetus infected with Neospora caninum from Lages, Santa Catarina, Brazil, is reported. Macroscopically, there was moderate flattening and narrowing of the skull, and the portion of the cerebral hemispheres was markedly reduced in size, measuring 3.5 × 3.
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