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Relationship Between Blood Groups and Cardiovascular Diseases: Insights From an Algerian Inpatient Study.
Cureus
December 2024
Cardiology Oncology Collaborative Research Groupe, Faculty of Medicine, University of Algiers Benyoucef Benkhedda, Algiers, DZA.
Introduction: Research on the association between blood groups and cardiovascular diseases (CVDs) in Africa, including Algeria, is notably limited, with a primary focus on blood donors. This narrow scope hinders a comprehensive understanding of the genetic diversity of blood groups and their potential links to CVD risk within the African context. To bridge this knowledge gap, this study proposes to investigate the distribution of blood group genotypes and their association with CVD prevalence, aiming to enhance knowledge within the African context and contribute to global insights into the relationship between blood groups and CVD.
View Article and Find Full Text PDFEvaluation of the LightCycler PRO Instrument as a Platform for Rhesus D Typing.
Biomedicines
August 2024
Red Cross Transfusion Service of Upper Austria, Krankenhausstrasse 7, 4020 Linz, Austria.
Rapid and reliable Rhesus D typing is crucial for blood donation centers. In instances of massive blood transfusion or reduced antigen expression, DNA-based phenotype prediction becomes mandatory. Our molecular typing approach involves an initial real-time PCR for the most common aberrant types in our region, (weak D type 1), (weak D type 2), (weak D type 3), and (DVII).
View Article and Find Full Text PDFMolecular Background of RhD-positive and RhD-negative Phenotypes in a Saudi Population.
Saudi J Med Med Sci
June 2024
Department of Clinical Laboratory Sciences, Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Background: The gene is one of the most complex blood group genes. The molecular background of the gene in RhD-negative and RhD-positive individuals varies within and among different populations. Knowing the molecular basis of the gene in a specific population is required to establish effective genotyping methods.
View Article and Find Full Text PDFThe Distribution Patterns of Rhesus (Rh) Antigens.
Cureus
June 2024
Transfusion Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Introduction: The determination of one's blood group is dictated by the inheritance-based diversity in the presence or absence of RBC antigens on the surface. Extended Rhesus (Rh) antigens are the most clinically relevant antigens of blood group systems after the ABO blood group system in transfusion medicine. The aim of this study was to serologically assess the prevalence of extended Rh antigens across diverse blood group systems.
View Article and Find Full Text PDFDNA Reference Reagents for Genotyping RH Variants.
J Mol Diagn
June 2024
Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland. Electronic address:
Patients who carry Rhesus (RH) blood group variants may develop Rh alloantibodies requiring matched red blood cell transfusions. Serologic reagents for Rh variants often fail to specifically identify variant Rh antigens and are in limited supply. Therefore, red blood cell genotyping assays are essential for managing transfusions in patients with clinically relevant Rh variants.
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