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Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the immune system maternal-fetal interface during palatal development.
J Mol Histol
December 2024
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.51, Weiliu Road, Jinan, Shandong Province, 250021, China.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an important environmental pollutant that disturbs the immune balance of the maternal-fetal interface (MFI) and is also a common environmental factor for the formation of cleft palate (CP). Therefore, the purpose is to investigate whether TCDD can cause CP by disrupting the immune balance of the maternal-fetal interface. Fifteen C57BL/6J mice were randomly assigned to three groups: control group, TCDD group, and TCDD plus Freund's complete adjuvant (FCA) (TCDD + FCA) group.
View Article and Find Full Text PDFEXPOSURE TO THE POLYCHLORINATED BIPHENYL MIXTURE AROCLOR 1254 ELICITS NEUROLOGICAL AND CARDIAC DEVELOPMENTAL EFFECTS IN EARLY LIFE STAGE ZEBRAFISH (Danio rerio).
Chemosphere
December 2024
University of North Texas, Department of Biological Sciences and Advanced Environmental Research Institute, Denton, TX, 76203. Electronic address:
The goal of this study was to compare the bioaccumulation of the PCB mixture Aroclor 1254 in zebrafish to cardiac and neurologic outcomes. The establishment of effect concentrations (ECs) for cardiac and neurotoxic effects of PCBs in early life stage fish is challenging due to a lack of measured PCB concentrations in test media (e.g.
View Article and Find Full Text PDFRelationships among CYP2B6 genetic variants and serum levels of multiple polychlorinated biphenyls and hydroxylated metabolites in a Japanese population.
J Hazard Mater
December 2024
Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606-8501, Japan. Electronic address:
Article Synopsis
- Production of polychlorinated biphenyls (PCBs) has been banned since 2001, but health risks from exposure continue due to their metabolism by enzymes like CYP2B6, where gene polymorphisms may influence this process.
- The study analyzed blood samples from 129 individuals to explore the relationship between specific CYP2B6 gene variants and levels of PCBs and their metabolites (OH-PCBs), finding variations in metabolism linked to different genotypes, particularly *1/*4 and *6/*6.
- Results showed that the *1/*4 genotype was correlated with higher metabolite-to-parent compound ratios for certain PCBs, while the *6/*6 genotype showed the opposite effect, indicating complex interactions between genetic factors
Influence of prenatal hexachlorobenzene, PCB and selenium levels on growth trajectories in the first year of life: Findings from the NEHO birth cohort.
Environ Int
December 2024
National Research Council of Italy, Institute for Biomedical Research and Innovation, Palermo, Italy.
Prenatal exposure to endocrine-disrupting chemicals (EDCs) may impact postnatal growth trajectories, increasing the risk of various diseases later in life. This issue is of particular concern in industrially contaminated areas, where environmental matrices contain mixtures of pollutants. This study aimed to evaluate the associations between cord serum concentrations of organochlorine pollutants (hexachlorobenzene-HCB and polychlorinated biphenyls-PCBs) and essential elements (EEs), and weight growth trajectories during the first year of life.
View Article and Find Full Text PDFHuman exposure to polychlorinated alkanes (C) in soil and dust from Nigerian e-waste sites: Occurrence, homologue pattern and health risk assessment.
J Hazard Mater
December 2024
Toxicological Centre, University of Antwerp, Universiteitsplein 1, Wilrijk 2610, Belgium. Electronic address:
Electronic waste (e-waste) dismantling and dumpsite processes are recognized as significant sources of chlorinated paraffin (CP) exposure. This study aims to investigate the environmental occurrence and distribution of polychlorinated alkanes (PCAs-C), specifically in soil and outdoor dust samples collected from e-waste dumpsites and automobile dismantling and resale sites in Nigeria. The results revealed a widespread occurrence of PCAs across all sampled locations.
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