AI Article Synopsis
- Cytogenetic studies of 3 male patients with terminal chronic myeloid leukemia revealed chromosome abnormalities, with varying numbers of Philadelphia chromosome (Ph1) translocations: 3 Ph1 in the first, 4 in the second, and 3 in the third.
- All cases showed the typical Ph1 translocation (t(9;22)(q34;q11)) and inconsistent counts of Ph1 and 9q+ chromosomes.
- The high frequency of multiple Ph1 translocations found in this study, part of a survey on 9 blastic-phase individuals, prompts questions about their origins and clinical implications.
Article Abstract
G-banded cytogenetic studies of 3 male patients in the terminal phase of chronic myeloid leukemia showed the following abnormalities: in the first case, the presence of a medullar cell line with 51 chromosomes and 3 Ph1; in the second case, a clone with 65 chromosomes and 4 Ph1, and in the third patient a clone with 53 chromosomes and 3 Ph1. In all 3 cases, G-banding revealed the Ph1 translocation to be of the usual type: t(9;22) (q34;q11) and there was discordance between the number of Ph1 and 9q+. There was no obvious correlation between the presence of multiple Ph1 and the clinical or cytological features. These 3 cases were detected as part of a recent G-banded cytogenetic survey of 9 individuals in the blastic phase studied by the authors. The frequency of multiple Ph1 observed in this sample of blastic-phase leukemia is unusually elevated, raising the question of the origin of such a high incidence.
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| http://dx.doi.org/10.1159/000207047 | DOI Listing |
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