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Neuroleptic Malignant Syndrome in a 10-Month-Old Ex-Preterm Infant with Delirium.
AJP Rep
July 2024
Division of Neonatology, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.
Article Synopsis
- - Atypical antipsychotics are increasingly used in the NICU to manage neonatal delirium, but caution is needed due to potential adverse effects like neuroleptic malignant syndrome (NMS).
- - NMS is a rare but serious reaction to antipsychotics, primarily seen in older children, but this case report highlights its occurrence in a 10-month-old infant treated with olanzapine.
- - Symptoms of NMS include hyperthermia and mental status changes, emphasizing the need for careful monitoring and management when prescribing antipsychotics to infants.
Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.
J Clin Sleep Med
January 2025
Department of Neurology, Vanderbilt University, Nashville, Tennessee.
Introduction: This guideline establishes clinical practice recommendations for treatment of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) in adults and pediatric patients.
Methods: The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assign strengths based on a systematic review of the literature and an assessment of the evidence using the grading of recommendations assessment, development, and evaluation methodology. The task force provided a summary of the relevant literature and the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations.
[Metabolic adverse drug reactions related to psychotropic drugs].
Fortschr Neurol Psychiatr
September 2024
Krankenhaus für Psychiatrie, Psychotherapie und Psychosomatische Medizin, Schloss Werneck, Werneck, Germany.
Metabolic adverse drug reactions (mADR) related to psychotropic drugs have significant health-related effects including weight gain, impaired glucose tolerance, diabetes mellitus and dyslipidemia as well as economic relevance. Nearly all antipsychotics (AP) and many antidepressants (AD) and mood stabilisers may induce weight gain. Weight development in the first weeks or months after the beginning of the therapy is the strongest predictor for weight gain related to AP and AD.
View Article and Find Full Text PDFThe annoyance of singultus: a case report of a rare adverse effect after epidural steroid injection.
BMC Anesthesiol
August 2024
Department of Anesthesiology, Stony Brook University Renaissance School of Medicine, 101 Nicolls Road, Health Sciences Center, Level 4, Stony Brook, NY, 11794, USA.
Objective: Cervical epidural steroid injections (ESIs) can provide effective pain management for patients suffering from chronic neck pain due to various pathological changes of the cervical spine. There are several rare adverse effects reported from interventional pain procedures, including persistent hiccups ("singultus"). Based on a limited number of cases, we propose a modified treatment algorithm for this adverse outcome (Fig.
View Article and Find Full Text PDFPharmacological treatment of cancer pain and opioid induced nausea and vomiting: online survey and comparison with current guidelines.
Support Care Cancer
June 2024
Interdisciplinary Center for Palliative Medicine, University Hospital Wuerzburg, Würzburg, Germany.
Purpose: We assumed that in Palliative Care, even in common clinical situations, the choice of drugs differs substantially between physicians. Therefore, we assessed the practice of pharmaceutical treatment choices of physicians for cancer pain and opioid-induced nausea and vomiting (OINV) and the rationale for their choices.
Methods: An online survey was conducted with physicians covering the following domains: i) Cancer pain therapy: non-opioids in addition to opioids: choice of drug ii) prevention of OINV: choice of drug and mode of application.
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