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Integrated multi-omics analysis and microbial recombinant protein system reveal hydroxylation and glycosylation involving nevadensin biosynthesis in Lysionotus pauciflorus.

Microb Cell Fact

September 2022

Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Background: Karst-adapted plant, Lysionotus pauciflours accumulates special secondary metabolites with a wide range of pharmacological effects for surviving in drought and high salty areas, while researchers focused more on their environmental adaptations and evolutions. Nevadensin (5,7-dihydroxy-6,8,4'-trimethoxyflavone), the main active component in L. pauciflours, has unique bioactivity of such as anti-inflammatory, anti-tubercular, and anti-tumor or cancer.

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Phenylpropenes represent a major subclass of plant volatiles, including eugenol, and ()-anethole. They contribute to the flavor and aroma of many chief herbs and spices, to exert distinct notes in food, , spicy anise- and clove-like to fruit. Asides from their culinary use, they appear to exert general health effects, whereas some effects are specific, e.

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Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.

Food Chem Toxicol

June 2022

University of Münster, Institute of Food Chemistry, Corrensstraße 45, 48149, Münster, Germany. Electronic address:

The present study focuses on the association between metabolic capacity and toxicity of the natural occurring flavonoid nevadensin in vitro. Human colon (HT29), liver (HepG2) and bone marrow (KG1) carcinoma cells were used and strong cell line dependent differences in toxic effect strength were found. HepG2 and KG1 cells were more sensitive against nevadensin treatment in comparison to HT29 cells.

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Prediction Mechanism of Nevadensin as Antibacterial Agent against : and Studies.

Comb Chem High Throughput Screen

August 2022

Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Sumedang, Indonesia.

Background: Streptococcus sanguinis can contribute to tooth demineralization, which can lead to dental caries. Antibiotics used indefinitely to treat dental caries can lead to bacterial resistance. Discovering new antibacterial agents from natural products, like Ocimum basilicum, will help combat antibiotic resistance.

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Comparison of the Phenolic Compound Profile and Antioxidant Potential of L. and L.

Molecules

March 2021

WALA Heilmittel GmbH, Department of Analytical Development & Research, Section Phytochemical Research, 73087 Bad Boll, Germany.

Article Synopsis
  • - The study compared two plant species, L. and L., focusing on their phenolic compounds and antioxidant activity using a specific radical assay.
  • - The ethyl acetate extract exhibited the strongest antioxidant activity, with specific compounds like luteolin and apigenin identified as effective scavengers present only in this fraction.
  • - Both species showed similar key compounds, but differences in individual compound concentrations were noted, indicating similar potential for phytotherapy benefits.
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