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Magnitude, risk factors and antimicrobial susceptibility pattern of and , among children with diarrhea in Southern Ethiopia: A Cross-sectional Study.
SAGE Open Med
April 2021
Biology Department, College of Computational Sciences, Hawassa University, Hawassa, Ethiopia.
Objective: This study was aimed at identifying and infection, their antibiotic susceptibility pattern and associated risk factors among children with diarrhea who attended Alamura Health Center.
Method: A facility-based cross-sectional study was conducted on 263 children aged below 14 years with diarrhea. A structured questionnaire was used to collect socio-demographic and clinical data after obtaining the necessary consent from their parents or caretakers.
The activity of ceftazidime, amikacin and sisomicin was investigated in an in vitro model using varying concentrations of antibiotic which mimic the serum levels of patients after the intramuscular administration of a 500, 250 and 70 mg dose respectively. Using this test, during the time of the agar MIC value correlation, ceftazidime, amikacin and sisomicin proved to be active against strains sensitive to 16 micrograms/ml, 8 micrograms/ml and 4 micrograms/ml respectively. Using the above concentrations as the cut-off points in defining the sensitivity of the strains, ceftazidime revealed the same level of activity as amikacin (6 and 5 resistant strains respectively out of the 185 tested) and proved much more active than sisomicin (48 resistant strains).
View Article and Find Full Text PDFA 14-year-old Black girl developed Serratia marcescens endocarditis following a mitral valve repair. This was refractory to treatment with several courses of antibiotics and valve replacement, and was eventually cured after a second valve replacement and treatment with ceftazidime (GR 20263 Glaxo), a new cephalosporin derivative.
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