The influence of selection and inbreeding on the sensitivity of laboratory mice to cytogenetic effect of thioTEPA was studied. Selection was started among genetically heterogenous "synthetic" population. The sensitivity of mice was estimated by the frequency of bone marrow cells with chromosome damages in males 24 hours after the treatment with 5 mg/kg of thioTEPA dose intraperitoneally. As a result, genetic determination of sensitivity to the mutagen was demonstrated and the TPS strain was developed which was 3 to 4 times more sensitive than "normal" standard strains.
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