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Crosstalk between prolactin, insulin-like growth factors, and thyroid hormones in feather growth regulation in neonatal chick wings.
Gen Comp Endocrinol
January 2025
Graduate School of Environmental, Life, Natural Science and Technology, Okayama University, 3-1-1 Kitaku, Tsushimanaka, Okayama 700-8530, Japan; Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Kitaku, Tsushimanaka, Okayama 700-8530, Japan. Electronic address:
The elongation of primary feathers in neonatal chicks is delayed by the late-feathering K gene located on the Z chromosome. We recently found that the K gene slows feather growth by reducing the number of functional prolactin (PRL) receptor (PRLR) dimers. In this study, we investigated the molecular mechanisms by which PRL promotes feather elongation.
View Article and Find Full Text PDFThyrotoxic Periodic Paralysis: A Unique Case Highlighting the Diagnostic Challenges and Management.
Cureus
November 2024
Internal Medicine Department, Saint Joseph Hospital, Jerusalem, PSE.
Thyrotoxic periodic paralysis (TPP) is a rare complication primarily associated with thyrotoxicosis, particularly in individuals with Graves' disease. While more common in males aged 20 to 40, it can occur across all ethnic backgrounds. It is the most common type of acquired periodic paralysis.
View Article and Find Full Text PDFNew-Onset Graves' Disease Induced by COVID-19: A Case Report and Literature Review.
Cureus
November 2024
Department of General Internal Medicine, Nakagami Hospital, Okinawa, JPN.
We present a case of new-onset Graves' disease in a 40-year-old woman following COVID-19 infection. The patient experienced hand tremors, palpitations, shortness of breath with minimal exertion, and excessive sweating one week after recovering from COVID-19. Thyroid function tests revealed thyrotoxicosis, elevated free thyroxine, free triiodothyronine, and suppressed thyroid-stimulating hormone levels.
View Article and Find Full Text PDFExposure to multiple metals and leukocyte telomere length in children and adolescents: The mediating effect of thyroid hormones.
Environ Res
January 2025
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education, And State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:
Exposure to metals has been related to alterations in leukocyte telomere length (LTL), an aging marker. However, the evidence regarding this relationship in children and adolescents, as well as the underlying mechanisms, remains unclear. Therefore, we aimed to explore the individual and mixture effects of metals on LTL in children and adolescents and to assess the mediating role of thyroid hormones and the modifying effect of a healthy lifestyle.
View Article and Find Full Text PDFPerinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams.
J Toxicol Sci
November 2024
Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd.
We propose a modified Comparative Thyroid Assay (CTA, USEPA) utilizing a smaller number of Sprague-Dawley rats (N=10/group) that assesses brain thyroid hormone (TH) concentrations and periventricular heterotopia while maintaining assay sensitivity. Our recent findings demonstrated that a prenatal test cohort of the modified CTA detected a dose-dependent decrease in maternal serum T3 (up to -26%) and T4 (up to -44%) with sodium phenobarbital (NaPB) exposure at 1000 ppm and 1500 ppm, equivalent to intakes of 60 and 84 mg/kg/day, respectively. On gestation day (GD) 20, fetuses exhibited reduced serum (-26%) and brain (-29%) TH concentrations, although these reductions were not dose dependent.
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