Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Gout is a disease caused by the deposit of monosodium urate (MSU) crystals that produce joint inflammation and subcutaneous nodules (tophi). The treatment of gout aims to reduce serum uric acid (sUA) levels by administering urate-lowering therapies (ULT) such as xanthine oxidase inhibitors (XOI: allopurinol, febuxostat) or uricosurics (e.g.
View Article and Find Full Text PDFEvaluation of Extract for Xanthine Oxidase Inhibition and Serum Uric Acid Reduction in a Hyperuricemic Mouse Model.
Pharmaceuticals (Basel)
November 2024
Independent Researcher, San Luis Potosí 78210, San Luis Potosí, Mexico.
: Current urate-lowering therapies may cause serious side effects in patients. Thus, alternative treatments are needed to regulate uric acid (UA) levels in patients with hyperuricemia associated with kidney injury, and natural antioxidant sources have demonstrated utility in this field. For the first time, our study evaluated the effects of an extract of insects on the levels of xanthine oxidase (XO) enzymes and synthetic free radicals in vitro and in vivo.
View Article and Find Full Text PDFTinospora crispa (L.) Hook.f. & Thomson vines ameliorates hyperuricemia by inhibiting synthesis and promoting excretion of uric acid through targeting NLRP3/caspase-1/IL-1β pathway.
J Ethnopharmacol
January 2025
Department of Rheumatology and Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, 510280, China; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, 510515, China; Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address:
Ethnopharmacological Relevance: Tinospora crispa (L.) Hook.f.
View Article and Find Full Text PDFAnti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice.
J Ethnopharmacol
January 2025
State Key Laboratory of Functions and Applications of Medicinal Plants & School of Pharmaceutical Sciences, Guizhou Medical University, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China; University Engineering Research Center for the Prevention and Treatment of Chronic Diseases By Authentic Medicinal Materials in Guizhou Province, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China; Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China. Electronic address:
Ethnopharmacological Relevance: The seeds of Hovenia acerba water extract (HAW) are used as an edible traditional Chinese medicine to treat diseases related to hyperuricemia (HUA).
Aim Of The Study: To evaluate HAW for its anti-HUA effect and to figure out their underlying mechanisms.
Materials And Methods: The anti-HUA effects were evaluated on a mouse model by testing HAW's effects on the levels of serum uric acid (SUA), the biochemical indicators of liver and kidney function, and the histology of liver and kidney.
Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia.
Biomedicines
November 2024
Academy of Military Medical Sciences, Beijing 100071, China.
: Uricase, or urate oxidase (Uox) is a key enzyme in uric acid (UA) metabolism and has been applied in clinical treatment of human hyperuricemia (HUA). However, the current clinically applied uricases, despite their potent urate-lowering capacity, tend to form anti-drug antibodies because of their immunogenicity, leading to increased risk of anaphylaxis, faster drug clearance and reduced or even complete loss of therapeutic effect, limiting their clinical application. In this study, we constructed engineered macrophages that stably expressed uricase, which might serve as a promising alternative to the direct injection of uricases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!