Strains of Pseudomonas aeruginosa resistant to gentamicin, tobramycin, streptomycin, and sulphonamide have been isolated from patients at two Sydney hospitals. The multiple resistance of all these strains was due to a transmissible plasmid. The significance of the identification of this plasmid, in this variety of strains and at two hospitals, for the treatment of Ps. aeruginosa infections is discussed.
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http://dx.doi.org/10.5694/j.1326-5377.1981.tb128318.x | DOI Listing |
JPEN J Parenter Enteral Nutr
January 2025
3rd Department of Internal Medicine-Metabolic Care and Gerontology, University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
Background: Antimicrobial lock therapy is recommended for preventing and treating catheter-related bloodstream infections, but different solutions have uncertain efficacy.
Methods: Two locks, 1.35% taurolidine and 4% ethylenediaminetetraacetic acid (EDTA), were tested on Staphylococcus epidermidis, Staphylococcus aureus, methicillin-resistant S.
Acta Med Indones
October 2024
Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia..
Background: Direct acting antivirals (DAAs) have demonstrated remarkable efficacy, in achieving hepatitis C viral (HCV) elimination rates higher than 90%. One particular concern associated with treatment failure is the emergence of resistance associated substitutions (RASs) in the genome. The occurrence of RASs highlights the adaptability and resilience of the HCV.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
January 2025
Infectious Disease Clinic, Dept. Of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy; Infectious Disease, Azienda Sanitaria Pesaro-Urbino, Pesaro, Italy.
Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) is a great cause of concern and it is often associated with bloodstream infections (BSIs) and a high mortality rate. We identified the risk factors of KPC-Kp BSIs observed in three Italian hospitals and studied the epidemiology of KPC-Kp strains.
Methods: We performed a retrospective analysis of KPC-Kp BSIs from 2014 to 2019 in three hospitals in Central Italy (Ancona, Pesaro-Fano, and Perugia).
J Biol Chem
January 2025
T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, 21218, USA. Electronic address:
Truncated hemoglobins (TrHbs) have an ancient origin and are widely distributed in microorganisms where they often serve roles other than dioxygen transport and storage. In extremophiles, these small heme proteins must have features that secure function under challenging conditions: at minimum, they must be folded, retain the heme group, allow substrates to access the heme cavity, and maintain their quaternary structure if present and essential. The genome of the obligate psychropiezophile Shewanella benthica strain KT99 harbors a gene for a TrHb belonging to a little-studied clade of globins (subgroup 2 of group N).
View Article and Find Full Text PDFComp Immunol Microbiol Infect Dis
January 2025
Laboratory of Epidemio-surveillance, Health, Production & Reproduction, Cell Therapy of Domestic and Wild Animals, Department of Veterinary Sciences, Faculty of Nature and Life Sciences, University of Chadli Bendjedid, El Tarf 36000, Algeria.
Animal trade has become a serious criminal practice in the world. Every day thousands of exotic wild animals, including reptiles, are farmed and sold worldwide. The illegal collection of turtles and tortoises remains completely unsupervised and represents a big challenge for responsible authorities.
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