AI Article Synopsis
- The study investigated the effects of thyroliberin (TRH) and its two analogues on the central nervous system (CNS) in rats.
- One analogue (pyroglutamyl-histidyl-prolinamide) decreased deep sleep duration and increased awakening, while exhibiting antagonistic effects on nembutal anesthesia.
- The other analogue (pyroglutamyl-seryl-glycinamide) increased sleep duration and reduced awakening time, without affecting nembutal's sedative effects, and neither analogue impacted TTH secretion.
Article Abstract
In experiments on rats, thyroliberin (TRH) and its analogue pyroglutamyl-histidyl-prolinamide stimulating effects on the CNS were shown. They produced a decrease in some phases of the sleep duration (particularly, in the deep one) and augmented the awakening period. At the same time, the antagonistic effect of these compounds with respect to nembutal anaesthesia was seen. On the contrary, TRH analogue pyroglutamyl-seryl-glycinamide decreased the awakening time and prolonged some phases of the sleep, not exerting antagonistic action on nembutal toxic effect. Both TRH analogues did not influence TTH secretion.
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