[Concentration of lipids and apolipoproteins A-I, A-II and E in blood plasma of men with chronic alcoholism].

Content of lipids and apolipoproteins A-I, A-II and E was studied in blood plasma of patients with chronic alcoholism under conditions of alcoholic abstinence syndrome and remission. Concentration of total cholesterol was higher by 10% in patients with alcoholic abstinence syndrome as compared with the control group of patients studied at the state of remission. Content of cholesterol in high density lipoproteins was increased up to 76.7 mg/100 ml as compared with 45.7 mg/100 ml in the controls. The increase in cholesterol content was accompanied by elevation in concentration of apo A-I from 132 to 169 mg/100 ml, whereas the content of apo A-II was increased by 9.2 mg/100 ml. In the patients the content of apo E tended to decrease. Content of triglycerides was increased by 20-25% in blood. All the alterations in concentration of lipids and apolipoproteins returned to the normal level after 3-4 weeks of abstinence from alcohol intake. The increase in content of cholesterol in high density lipoproteins and of these lipoproteins was apparently due to stimulation of these substances formation and inhibition of their catabolism in liver tissue impaired with alcohol.