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A Case Report on 46,XX Male Difference of Sex Development.
Cureus
September 2024
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo Antônio de Santo António, Porto, PRT.
The 46,XX male syndrome is a very rare disorder/difference of sex development (DSD). Characterized by a 46,XX karyotype with a male phenotype and various abnormalities, including virilized external genitalia, small testes, hypergonadotropic hypogonadism, and azoospermia. Primarily described in small population studies and clinical reports, much remains to be understood about the prevalence of clinical manifestations, treatment outcomes, and long-term follow-up in this disorder.
View Article and Find Full Text PDFDulaglutide rescues the elevated testicular dysfunction in a mouse model of high-fat diet-induced obesity.
Mutat Res Genet Toxicol Environ Mutagen
August 2024
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Obesity is a well-known risk factor for testicular function; however, dulaglutide's effect on the testis in obesity has received little attention. Currently, clinicians prescribe the antidiabetic drug dulaglutide only off-label for weight management in non-diabetics. Investigating the impact of this novel compound on obesity is critical for determining whether it has any disruptive effects on testicular cells.
View Article and Find Full Text PDFImpacts of the DPP-4 Inhibitor Saxagliptin and SGLT-2 Inhibitor Dapagliflozin on the Gonads of Diabetic Mice.
Biomedicines
September 2023
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Diabetes mellitus is a metabolic disease that can cause systemic problems, including testicular dysfunction. Several diabetes medications have demonstrated potential adverse effects on the male reproductive system; however, the effects of saxagliptin and dapagliflozin have not been sufficiently examined. This investigation studied the impacts of saxagliptin and dapagliflozin treatments on the gonads in a male mouse model of diabetes.
View Article and Find Full Text PDFHomozygosity for a novel INHA mutation in two male siblings with hypospadias, primary hypogonadism, and high-normal testicular volume.
Eur J Endocrinol
March 2022
Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey.
Background: The human INHA gene encodes the inhibin subunit alpha protein, which is common to both inhibin A and B. The functional importance of inhibins in male sex development, sexual function, and reproduction remain largely unknown.
Objective: We report for the first time two male siblings with homozygous INHAmutations.
Use and Effectiveness of Sperm Cryopreservation for Adolescents and Young Adults: A 37-Year Bicentric Experience.
J Adolesc Young Adult Oncol
February 2021
Pediatric Onco-Hematology Unit, Department of Woman, Child and Adolescent, Geneva University Hospitals, Geneva, Switzerland.
Sperm cryopreservation (SCP) should be offered to every adolescent before gonadotoxic treatment, but experience in this age range is still relatively limited. The goal of this study is to assess how to optimize this procedure. One hundred thirty-three patients between 12 and 20 years old, who underwent SCP between 1980 and 2017, were included.
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