Changes in smooth pursuit eye tracking of horizontal sinusoidal target movement before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced a dose-dependent reduction in gain of pursuit eye movements at target frequencies of 0.4--1.6 Hz. Cross-correlation of eye and track was significantly reduced at most frequencies showing gain reduction after 10 mg diazepam. Eye-target phase relationship was not systematically altered by drug. Visual inspection of smooth pursuit tracking records showed reduced peak-to-peak amplitude of eye tracking along with replacement of smooth pursuit with saccadic pursuit, especially after 10 mg. Changes in smooth pursuit eye tracking after diazepam were similar to those changes reported in the literature associated with olivopontocerebellar atrophy and were quite unlike the changes in smooth pursuit after opiates, as previously reported. The role of cerebellar benzodiazepine binding sites in diazepam disruption of eye tracking was discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00427101 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The eyes have it: Alcohol-induced eye movement impairment and perceived impairment in older adults with and without alcohol use disorder.
Alcohol Clin Exp Res (Hoboken)
January 2025
Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
Background: While alcohol has been shown to impair eye movements in young adults, little is known about alcohol-induced oculomotor impairment in older adults with longer histories of alcohol use. Here, we examined whether older adults with chronic alcohol use disorder (AUD) exhibit more acute tolerance than age-matched light drinkers (LD), evidenced by less alcohol-induced oculomotor impairment and perceived impairment.
Method: Two random-order, double-blinded laboratory sessions with administration of alcohol (0.
The primary aim of this descriptive cross-sectional study was to examine the relationship between ocular motility and motor skills in school-age children. Participants included 142 schoolchildren (mean age: 7.08 ± 0.
View Article and Find Full Text PDFApathy in Alzheimer's disease: Eye movements characteristics and neurostructural basis.
J Affect Disord
January 2025
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: We sought to evaluate the characteristics of eye movements in Alzheimer's disease (AD) patients with apathy (AD-A) and their ability to identify AD-A and explore the shared neurostructure of eye movements and apathy.
Methods: Total 32 normal controls, 36 AD-A and 72 AD with no apathy (AD-NA) patients were recruited. Parameters of smooth pursuit, fixation, prosaccade and antisaccade were compared among the three groups.
The vestibular and oculomotor dysfunction in Fabry disease: a cohort study in China.
Ann Med
December 2025
Department of Neurology, Peking University First Hospital, China.
Objective: Whereas a few studies have evaluated vestibular involvement in Fabry disease (FD), the relationship between vestibular/oculomotor abnormalities and disease-specific biomarkers remain unclear. Therefore, we seek to evaluate these quantitatively and analyze their relationship with disease phenotype and biomarkers in FD.
Methods: This cohort study enrolled 37 Chinese FD patients registered in our center.
A comparative analysis of perceptual noise in lateral and depth motion: Evidence from eye tracking.
J Vis
January 2025
Vision and Control of Action (VISCA) Group, Department of Cognition, Development and Psychology of Education, Institut de Neurociències, Universitat de Barcelona, Barcelona, Catalonia, Spain.
The characterization of how precisely we perceive visual speed has traditionally relied on psychophysical judgments in discrimination tasks. Such tasks are often considered laborious and susceptible to biases, particularly without the involvement of highly trained participants. Additionally, thresholds for motion-in-depth perception are frequently reported as higher compared to lateral motion, a discrepancy that contrasts with everyday visuomotor tasks.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!