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Replication stress induces POLQ-mediated structural variant formation throughout common fragile sites after entry into mitosis.
Nat Commun
November 2024
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Article Synopsis
- Genomic structural variants (SVs) significantly affect human health, yet the processes behind the formation of large, nonrecurrent changes remain largely unclear.
- Common fragile sites (CFSs) serve as a model for studying SV formation, particularly large deletions, under conditions of replication stress.
- Research shows that SV junctions accumulate at a higher rate during cell division (M-phase) and primarily involve a specific DNA repair process driven by DNA polymerase theta (POLQ), rather than relying on traditional mitotic DNA synthesis methods.
Timeless-Tipin interactions with MCM and RPA mediate DNA replication stress response.
Front Cell Dev Biol
February 2024
Cell Biology and Epigenetics, Department of Biology, Technical University of Darmstadt, Darmstadt, Germany.
The accuracy of replication is one of the most important mechanisms ensuring the stability of the genome. The fork protection complex prevents premature replisome stalling and/or premature disassembly upon stress. Here, we characterize the Timeless-Tipin complex, a component of the fork protection complex.
View Article and Find Full Text PDFIrreversible inhibition of TRF2 recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells.
Cell Chem Biol
December 2023
DiSTABiF, University of Campania "Luigi Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy. Electronic address:
The TRF2 shelterin component is an essential regulator of telomere homeostasis and genomic stability. Mutations in the TRF2 domain physically impair t-loop formation and prevent the recruitment of several factors that promote efficient telomere replication, causing telomeric DNA damage. Here, we design, synthesize, and biologically test covalent cyclic peptides that irreversibly target the TRF2 domain.
View Article and Find Full Text PDFEvidence of interactions among apoptosis, cell proliferation, and dedifferentiation in the rudiment during whole-organ intestinal regeneration in the sea cucumber.
Dev Biol
January 2024
Department of Biology, University of Puerto Rico, Río Piedras, PR, USA. Electronic address:
Article Synopsis
- Sea cucumbers, particularly Holothuria glaberrima, have a unique ability to regenerate their intestines by eviscerating internal organs under stress, with new growth beginning from the mesentery within weeks.
- Recent research explored the cellular processes involved in this regeneration, focusing on apoptosis, cell proliferation, and muscle cell dedifferentiation, but their exact roles are still unclear.
- Experiments using inhibitors showed that while apoptosis and cell proliferation did not significantly impact rudiment size, inhibiting apoptosis reduced cell proliferation and affected the timing of muscle cell changes, suggesting a complex relationship in regenerative processes.
Replisome loading reduces chromatin motion independent of DNA synthesis.
Elife
October 2023
Department of Biology, Technical University of Darmstadt, Darmstadt, Germany.
Chromatin has been shown to undergo diffusional motion, which is affected during gene transcription by RNA polymerase activity. However, the relationship between chromatin mobility and other genomic processes remains unclear. Hence, we set out to label the DNA directly in a sequence unbiased manner and followed labeled chromatin dynamics in interphase human cells expressing GFP-tagged proliferating cell nuclear antigen (PCNA), a cell cycle marker and core component of the DNA replication machinery.
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